RT Journal
A1 Huang K, Zou C, Yang X, Chen X, Liang L
T1 CArotid intima-media thickness and serum endothelial marker levels in obese children with metabolic syndrome
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2010
FD September 1
VO 164
IS 9
SP 846
OP 851
DO 10.1001/archpediatrics.2010.160
UL http://dx.doi.org/10.1001/archpediatrics.2010.160
AB Objective 
    To investigate carotid intima-media thickness (IMT) and serum endothelial marker levels in obese Chinese children.Design 
    Observational and descriptive study.Setting 
    Hangzhou, China.Participants 
    A total 131 obese children, including 29 with at least 2 components of metabolic syndrome (MS) (MS group), 102 with less than 2 components of MS (obese group), and 31 nonobese children (control group) were enrolled.Main Outcome Measures 
    Intima-media thickness, von Willebrand factor (vWF) level, and thrombomodulin level.Results 
    Compared with the control group, the obese group had greater IMT and higher vWF level (P < .05 for all). The mean (SD) vWF levels in the obese, MS, and control groups were 2.08 (0.78), 2.42 (0.98), and 1.54 (0.48) IU/mL, respectively, which were significantly different (P < .001). Intima-media thickness in the obese and MS groups was significantly greater than that in the control group. Intima-media thickness in the MS group was greater than that in the obese group. Multiple regression analysis showed that ratio of waist to height, vWF level, and triglycerides level were independent determinants of IMT.Conclusions 
    Our findings suggest endothelial injury in obese children. Intima-media thickness and vWF level might be useful to identify the degree of endothelial damage.