RT Journal A1 Wilson DM T1 ANalysis of metformin treatment for adolescent obesity at 48 rather than 24 weeks after treatment cessation—reply JF Archives of Pediatrics & Adolescent Medicine JO Archives of Pediatrics & Adolescent Medicine YR 2010 FD July 1 VO 164 IS 7 SP 678 OP 679 DO 10.1001/archpediatrics.2010.111 UL http://dx.doi.org/10.1001/archpediatrics.2010.111 AB The a priori primary end point of the study was change in adjusted BMI at the 52-week point. We fully expected that if there was an effect of metformin on BMI it would wane after drug treatment was stopped. We confirmed this expectation.