RT Journal
A1 Stark LJ, Quittner AL, Powers SW, et al
T1 RAndomized clinical trial of behavioral intervention and nutrition education to improve caloric intake and weight in children with cystic fibrosis
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2009
FD October 5
VO 163
IS 10
SP 915
OP 921
DO 10.1001/archpediatrics.2009.165
UL http://dx.doi.org/10.1001/archpediatrics.2009.165
AB Objective 
    To evaluate the efficacy of a behavioral plus nutrition education intervention, Be In CHARGE!, compared with that of a nutrition education intervention alone on caloric intake and weight gain in children with cystic fibrosis and pancreatic insufficiency.Design 
    Randomized controlled trial.Setting 
    Cystic fibrosis centers in the eastern, midwestern, and southern United States.Participants 
    Seventy-nine children aged 4 to 12 years below the 40th percentile for weight for age were recruited. Sixty-seven completed the intervention and 59 completed a 24-month follow-up assessment.Intervention 
    Comparison of a behavioral plus nutrition education intervention with a nutrition education intervention alone.Main Outcome Measures 
    Primary outcomes were changes from pretreatment to posttreatment in caloric intake and weight gain. Secondary outcomes were changes from pretreatment to posttreatment in percentage of the estimated energy requirement and body mass index z score. These outcomes were also examined 24 months posttreatment.Results 
    After treatment, the behavioral plus nutrition education intervention as compared with the nutrition education intervention alone had a statistically greater average increase on the primary and secondary outcomes of caloric intake (mean, 872 vs 489 cal/d, respectively), percentage of the estimated energy requirement (mean, 148% vs 127%, respectively), weight gain (mean, 1.47 vs 0.92 kg, respectively), and body mass index z score (0.38 vs 0.18, respectively). At the 24-month follow-up, children in both conditions maintained an estimated energy requirement of around 120% and did not significantly differ on any outcomes.Conclusions 
    A behavioral plus nutrition education intervention was more effective than a nutrition education intervention alone at increasing dietary intake and weight over a 9-week period. However, across the 24-month follow-up, both treatments achieved similar outcomes.Trial Registration 
    clinicaltrials.gov Identifier: NCT00006169