RT Journal
A1 Aucouturier J, Meyer M, Thivel D, Taillardat M, Duché P
T1 EFfect of android to gynoid fat ratio on insulin resistance in obese youth
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2009
FD September 7
VO 163
IS 9
SP 826
OP 831
DO 10.1001/archpediatrics.2009.148
UL http://dx.doi.org/10.1001/archpediatrics.2009.148
AB Background 
    Upper body fat distribution is associated with the early development of insulin resistance in obese children and adolescents.Objective: 
    To determine if an android to gynoid fat ratio is associated with the severity of insulin resistance in obese children and adolescents, whereas peripheral subcutaneous fat may have a protective effect against insulin resistance.Setting 
    The pediatric department of University Hospital, Clermont-Ferrand, France.Design 
    A retrospective analysis using data from medical consultations between January 2005 and January 2007.Participants 
    Data from 66 obese children and adolescents coming to the hospital for medical consultation were used in this study.Main Outcome Measures 
    Subjects were stratified into tertiles of android to gynoid fat ratio determined by dual-energy x-ray absorptiometry. Insulin resistance was assessed by the homeostasis model of insulin resistance (HOMA-IR) index.Results 
    There were no differences in weight, body mass index, and body fat percentage between tertiles. Values of HOMA-IR were significantly increased in the 2 higher tertiles (mean [SD], tertile 2, 2.73 [1.41]; tertile 3, 2.89 [1.28]) compared with the lower tertile (tertile 1, 1.67 [1.24]) of android to gynoid fat ratio (P < .001). The HOMA-IR value was significantly associated with android to gynoid fat ratio (r = 0.35; P < .01).Conclusions 
    Android fat distribution is associated with an increased insulin resistance in obese children and adolescents. An android to gynoid fat ratio based on dual-energy x-ray absorptiometry measurements is a useful and simple technique to assess distribution of body fat associated with an increased risk of insulin resistance.