RT Journal
A1 Goldstein LH, Berlin M, Kozer E, Berkovitch M
T1 STill wary of rectal acetaminophen—reply
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2009
FD May 4
VO 163
IS 5
SP 491
OP 492
DO 10.1001/archpediatrics.2009.82
UL http://dx.doi.org/10.1001/archpediatrics.2009.82
AB 
We thank Drs Ousterhoudt and Henretig for their comments. The American Academy of Pediatrics' recommendation to refrain from rectal acetaminophen was based on pharmacokinetic studies showing great variation of peak levels of acetaminophen administered rectally, often not achieving therapeutic levels, with longer time to peak concentrations.1 Our meta-analysis showed that pharmacodynamic variables, such as temperature reduction, were similar with rectal and oral administration.2