RT Journal A1 Davis MM, Shah SS T1 NEcessary innovations in immunization delivery JF Archives of Pediatrics & Adolescent Medicine JO Archives of Pediatrics & Adolescent Medicine YR 2009 FD May 4 VO 163 IS 5 SP 483 OP 485 DO 10.1001/archpediatrics.2009.72 UL http://dx.doi.org/10.1001/archpediatrics.2009.72 AB Nevertheless, childhood vaccination in the 21st century faces multiple challenges that threaten its success. An increasingly skeptical public questions whether vaccines are safe enough, leading to underimmunization of large segments of the population in some regions. Periodic vaccine shortages necessitate prioritizing vaccines for the highest-risk populations, leading to delayed immunization of many young children. Waning immunity and low vaccination rates among adults leave the most vulnerable children underprotected against some vaccine-preventable diseases, leading to communitywide outbreaks of infections such as pertussis. Lastly, newly recommended vaccines for adolescents are targeted to a population renowned for low health care use rates.