RT Journal
A1 Ventura E, Davis J, Byrd-Williams C, et al
T1 REduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight latino adolescents
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2009
FD April 6
VO 163
IS 4
SP 320
OP 327
DO 10.1001/archpediatrics.2009.11
UL http://dx.doi.org/10.1001/archpediatrics.2009.11
AB Objective 
    To examine if reductions in added sugar intake or increases in fiber intake in response to a 16-week intervention were related to improvements in metabolic outcomes related to type 2 diabetes mellitus risk.Design 
    Secondary analysis of a randomized control trial.Setting 
    Intervention classes at a lifestyle laboratory and metabolic measures at the General Clinical Research Center.Participants 
    Fifty-four overweight Latino adolescents (mean [SD] age, 15.5 [1] years).Intervention 
    Sixteen-week study with 3 groups: control, nutrition, or nutrition plus strength training.Main Outcome Measures 
    Body composition by dual-energy x-ray absorptiometry; visceral adipose tissue by magnetic resonance imaging; glucose and insulin incremental area under the curve by oral glucose tolerance test; insulin sensitivity, acute insulin response, and disposition index by intravenous glucose tolerance test; and dietary intake by 3-day records.Results 
    Fifty-five percent of all participants decreased added sugar intake (mean decrease, 47 g/d) and 59% increased fiber intake (mean increase, 5 g/d), and percentages were similar in all intervention groups, including controls. Those who decreased added sugar intake had an improvement in glucose incremental area under the curve (−15% vs +3%; P = .049) and insulin incremental area under the curve (−33% vs −9%; P = .02). Those who increased fiber intake had an improvement in body mass index (−2% vs +2%; P = .01) and visceral adipose tissue (−10% vs no change; P = .03).Conclusions 
    Individuals who reduced added sugar intake by the equivalent of 1 can of soda per day or increased fiber intake by the equivalent of a cup of beans showed improvements in key risk factors for type 2 diabetes, specifically in insulin secretion and visceral fat. Improvements occurred independent of group assignment and were equally likely to occur in control group participants.Trial Registration 
    clinicaltrials.gov Identifier: NCT00697580