RT Journal A1 McNall M, Remafedi G T1 RElationship of amphetamine and other substance use to unprotected intercourse among young men who have sex with men JF Archives of Pediatrics & Adolescent Medicine JO Archives of Pediatrics & Adolescent Medicine YR 1999 FD November 1 VO 153 IS 11 SP 1130 OP 1135 DO 10.1001/archpedi.153.11.1130 UL http://dx.doi.org/10.1001/archpedi.153.11.1130 AB Objectives  To analyze temporal trends in drug use and the relationship between drug use before or during sex and unprotected intercourse among a sample of young gay and bisexual men.Methods  Data were obtained from cross-sectional surveys of 9 annual cohorts. Respondents were 877,13- to 21-year-old gay and bisexual male volunteers. Trends in the use of substances before or during sex were analyzed. Univariate and multivariate measures of the association between substance use before or during sex and unprotected anal intercourse were calculated.Results  Between 1994 and 1997, the use of marijuana, cocaine, amphetamines, and mean scores on a measure of overall drug use severity increased significantly in a sample of young gay and bisexual men. Significant univariate associations were found between drug use before or during sex and unprotected anal intercourse for the following substances: alcohol, marijuana, cocaine, amphetamines, barbiturates, heroin, LSD, volatile nitrites, tranquilizers, and methaqualone. In multivariate analyses, however, only cocaine use predicted failure to use condoms during anal intercourse.Conclusion  Although amphetamine and other drug use increased among young gay and bisexual men, only cocaine use was a significant, independent predictor of the failure to use condoms during anal intercourse.