RT Journal
A1 Lobaugh NJ, Karaskov V, Rombough V, et al
T1 PIracetam therapy does not enhance cognitive functioning in children with down syndrome
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2001
FD April 1
VO 155
IS 4
SP 442
OP 448
DO 10.1001/archpedi.155.4.442
UL http://dx.doi.org/10.1001/archpedi.155.4.442
AB Background 
    Piracetam is widely used as a purported means of improving cognitive function in children with Down syndrome. Its efficacy, however, has not been rigorously assessed.Objective 
    To determine whether 4 months of piracetam therapy (80-100 mg/kg per day) enhances cognitive function in children with Down syndrome.Design 
    A randomized, double-blind, placebo-controlled crossover study.Participants and Methods 
    Twenty-five children with Down syndrome (aged 6.5-13 years) and their caregivers participated. After undergoing a baseline cognitive assessment, children were randomly assigned to 1 of 2 treatment groups: piracetam-placebo or placebo-piracetam.Main Outcome Measure 
    The difference in performance while taking piracetam vs while taking placebo on tests assessing a wide range of cognitive functions, including attention, learning, and memory.Results 
    Eighteen children completed the study, 4 withdrew, and 3 were excluded at baseline. Piracetam therapy did not significantly improve cognitive performance over placebo use but was associated with central nervous system stimulatory effects in 7 children: aggressiveness (n = 4), agitation or irritability (n = 2), sexual arousal (n = 2), poor sleep (n = 1), and decreased appetite (n = 1).Conclusion 
    Piracetam therapy did not enhance cognition or behavior but was associated with adverse effects.