RT Journal
A1 Feudtner C
T1 CHild advocacy and robust community-centered research
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2001
FD April 1
VO 155
IS 4
SP 438
OP 439
DO 10.1001/archpedi.155.4.438
UL http://dx.doi.org/10.1001/archpedi.155.4.438
AB 
DOES THE DRUG piracetam improve the cognition of children with Down syndrome?1 In contrast with exuberant testimonials appearing on television and the Internet, Lobaugh et al2 found no substantial benefit in their randomized controlled study. Despite the trial's relatively small cohort size, its rigorous double-blinded crossover design should earn our respect, while their findings (especially of undesirable behavioral effects) should temper our enthusiasm for piracetam markedly.