RT Journal
A1 Hannula A, Perhomaa M, Venhola M, Pokka T, Renko M, Uhari M
T1 LOng-term follow-up of patients after childhood urinary tract infection
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2012
FD December 1
VO 166
IS 12
SP 1117
OP 1122
DO 10.1001/archpediatrics.2012.1383
UL http://dx.doi.org/10.1001/archpediatrics.2012.1383
AB Objective 
                  To evaluate the long-term outcome of children with urinary tract infection (UTI).Design 
                  Follow-up examination 6 to 17 years after childhood UTI.Setting 
                  Secondary to tertiary referral center.Patients 
                  From an original population-based cohort of 1185 children with a history of UTI on whom both ultrasonography (US) and voiding cystourethrography had been performed between January 1, 1993, and December 31, 2003, we excluded 24 cases with major renal dysplasia or obstruction of the urinary tract to form a study cohort of 1161 patients. We took a stratified random sample of 228 patients for follow-up, and a total of 193 (85%) participated. Of the 193 participating patients, 103 (53%) had received antibiotic prophylaxis and 42 (22%) had undergone surgery.Main Exposure 
                  Urinary tract infection.Main Outcome Measures 
                  Renal growth and parenchymal damage in US examination, kidney function, and blood pressure.Results 
                  Unilateral renal parenchymal defect was found in 22 of the 150 patients (15%) studied with US at follow-up, and unilateral kidney growth retardation was found in 5 patients (3%). All but 1 of the renal parenchymal defects seen on US were in patients with grade III to V vesicoureteral reflux. Despite the parenchymal defects seen on US, the serum cystatin C concentration, estimated glomerular filtration rate, and blood pressure were within the normal ranges in all patients.Conclusions 
                  The risk of long-term consequences from childhood UTI seems to be very low. Owing to the observational nature of our study, we cannot exclude the effects of the given treatment on the outcome of our patients.