RT Journal
A1 ISRAELS S, MUTH HH, ZEAVIN II
T1 NEphrolithiasis with renal tubular failure
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1949
FD September 1
VO 78
IS 3
SP 389
OP 392
DO 10.1001/archpedi.1949.02030050402012
UL http://dx.doi.org/10.1001/archpedi.1949.02030050402012
AB FAILURE of a single function of the renal tubules has been a well recognized entity. Thus, Thorn and his associates1 reported a case of "salt-losing nephritis" which so closely simulated adrenocortical hypofunction (Addison's disease) that it went unrecognized for some time. Albright and his co-workers2 gathered together and reported 9 cases of nephrolithiasis and nephrocalcinosis in which they showed that the primary defect lay in the inability of the renal tubules to form ammonia. This resulted in the loss of fixed base, with precipitation of calcium salts in the tubules and renal pelves. Loss of fixed base other than calcium may occur; potassium deficiency with resulting paralysis has been reported by Brown, Currens and Marchand3 in a case of chronic nephritis in which tubular formation of ammonia had failed.The case presented herein shows many of the features of those described by Albright and his associates.REPORT