RT Journal
A1 ROSENTHAL S
T1 MEthods of bcg production and vaccination
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1949
FD March 1
VO 77
IS 3
SP 377
OP 380
DO 10.1001/archpedi.1949.02030040387011
UL http://dx.doi.org/10.1001/archpedi.1949.02030040387011
AB IN A REPORT by the United States Public Health Service,1 as well as in one made for the British government,2 it was agreed that BCG production should be carried out by a central laboratory. The reasons for this universal agreement were: (1) to afford a standard method of comparison; (2) to maintain the fastidiousness of the organism; (3) to guarantee the minute care necessary in production of the vaccine, as the final product is a living organism to which no preservative can be added, and (4) to insure accurate and careful determination of the virulence.If such a program is followed, the results of vaccination in human subjects in various parts of the country can be readily correlated and the stability of the organisms assured.HISTORIC ASPECTS 
    A review of the literature reveals that "accidents" have occurred when central laboratories well qualified to produce the vaccine were not