RT Journal A1 FRANCIS CC T1 FActors influencing appearance of centers of ossification during early childhood JF American Journal of Diseases of Children JO American Journal of Diseases of Children YR 1939 FD April 1 VO 57 IS 4 SP 817 OP 830 DO 10.1001/archpedi.1939.01990040081005 UL http://dx.doi.org/10.1001/archpedi.1939.01990040081005 AB In a previous paper Werle and I1 presented a schedule for date and sequence of appearance of centers of ossification in young children. It is the purpose of this report to show how the epiphysial rating may be used as a measure of constitutional health and how specific disturbances affect the schedule.The centers at the wrist are particularly sensitive to disturbance and by their several stages of progress betray a previous disturbance in health. Roentgenograms of the left hand and wrist of each of several 5 year old boys, together with a brief health report on each, illustrate how the carpal area records fluctuations in health.The left hand of the first of these boys at the age of 5 years is shown in figure 2. The boy was weaned at 6 weeks, and there was considerable difficulty in finding a suitable substitute formula. During most of his