RT Journal
A1 VOLLMER H
T1 DIstribution of vitamin d in body after administration of massive doses
JF American Journal of Diseases of Children
JO American Journal of Diseases of Children
YR 1939
FD February 1
VO 57
IS 2
SP 343
OP 348
DO 10.1001/archpedi.1939.01990020101010
UL http://dx.doi.org/10.1001/archpedi.1939.01990020101010
AB Since my report1 in 1928 on the efficacy of massive doses of vitamin D in the treatment of rickets, numerous communications2 have appeared abroad which corroborate my findings. In the second half of the winter 1937-1938 I further confirmed my observation that rickets and tetany can be cured by peroral administration of a single dose of 600,000 international units of vitamin D and that the curative effect of this treatment is superior to that of the daily administration of small doses. These results can be explained only as due to the retention and storage of this massive dose of vitamin D.From my first experimental studies1 I have drawn the conclusion that rats are able to retain and utilize vitamin D given in one or in several massive doses. Recently Windorfer2h showed that this is true of infants. He advanced definite evidence that on the average