RT Journal
A1 Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA
T1 Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2012
FD June 1
VO 166
IS 6
SP 558
OP 566
DO 10.1001/archpediatrics.2011.1772
UL http://dx.doi.org/10.1001/archpediatrics.2011.1772
AB Objective 
                  To establish the evidence of therapeutic hypothermia for newborns with hypoxic ischemic encephalopathy (HIE).Data Sources 
                  Cochrane Central Register of Controlled Trials, Oxford Database of Perinatal Trials, MEDLINE, EMBASE, and previous reviews.Study Selection 
                  Randomized controlled trials that compared therapeutic hypothermia to normothermia for newborns with HIE.Intervention 
                  Therapeutic hypothermia.Main Outcome Measures 
                  Death or major neurodevelopmental disability at 18 months.Results 
                  Seven trials including 1214 newborns were identified. Therapeutic hypothermia resulted in a reduction in the risk of death or major neurodevelopmental disability (risk ratio [RR], 0.76; 95% CI, 0.69-0.84) and increase in the rate of survival with normal neurological function (1.63; 1.36-1.95) at age 18 months. Hypothermia reduced the risk of death or major neurodevelopmental disability at age 18 months in newborns with moderate HIE (RR, 0.67; 95% CI, 0.56-0.81) and in newborns with severe HIE (0.83; 0.74-0.92). Both total body cooling and selective head cooling resulted in reduction in the risk of death or major neurodevelopmental disability (RR, 0.75; 95% CI, 0.66-0.85 and 0.77; 0.65-0.93, respectively).Conclusion 
                  Hypothermia improves survival and neurodevelopment in newborns with moderate to severe HIE. Total body cooling and selective head cooling are effective methods in treating newborns with HIE. Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns.