RT Journal
A1 Zickafoose JS, Benneyworth BD, Riebschleger MP, Espinosa CM, Davis MM
T1 HOspitalizations for intussusception before and after the reintroduction of rotavirus vaccine in the united states
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2012
FD April 1
VO 166
IS 4
SP 350
OP 355
DO 10.1001/archpediatrics.2011.1501
UL http://dx.doi.org/10.1001/archpediatrics.2011.1501
AB Objective 
                  To determine whether hospital discharges for intussusception in children younger than 1 year have changed since the reintroduction of rotavirus vaccine in the United States.Design 
                  Serial cross-sectional analysis.Setting 
                  US hospitals.Participants 
                  Children younger than 1 year with a discharge diagnosis of intussusception identified in the Kids' Inpatient Database, a series of nationally representative data sets of pediatric hospital discharges in the United States with 4 available years prior to vaccine reintroduction (1997, 2000, 2003, and 2006) and 1 year after (2009).Main Exposures 
                  Hospital discharge before vs after rotavirus vaccine reintroduction.Outcome Measures 
                  Total number and rate of hospital discharges for infants younger than 1 year with a diagnosis of intussusception (International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0).Results 
                  From 1997 to 2006, there was no change in the total number of hospital discharges for intussusception, with a small decrease in the rate of intussusception discharges (41.6 [95% CI, 36.7-46.5] to 36.5 [95% CI, 31.7-41.2] per 100 000 infants). Based on the trend, the predicted rate of discharges for intussusception in 2009 was 36.0 (95% CI, 30.2-41.8) per 100 000 infants. The measured rate of hospital discharges for intussusception in 2009 was 33.3 (95% CI, 29.0-37.6) per 100 000 infants.Conclusion 
                  The reintroduction of rotavirus vaccine since 2006 has not resulted in a detectable increase in the number of hospital discharges for intussusception among US infants.