RT Journal
A1 Nolan SM, Prasad P, Fiks AG, Zaoutis T, TenHave TR, Coffin SE
T1 EFfect of rotavirus vaccine on reducing acute gastroenteritis in a large outpatient pediatric network
JF Archives of Pediatrics & Adolescent Medicine
JO Archives of Pediatrics & Adolescent Medicine
YR 2012
FD March 1
VO 166
IS 3
SP 232
OP 239
DO 10.1001/archpediatrics.2011.628
UL http://dx.doi.org/10.1001/archpediatrics.2011.628
AB Objectives 
                  To measure the effect of rotavirus vaccine (RVV) on acute gastroenteritis (AGE) managed by primary care physicians in the first 2 rotatvirus seasons following the introduction of RVV.Design 
                  Retrospective cohort study.Setting 
                  Practice-based network composed of 33 ambulatory pediatric practices in Philadelphia, Pennsylvania.Participants 
                  All children born from February 22, 2006 (date of RVV licensure), through February 29, 2008, and who received care at any network site.Main Exposure 
                  Receipt of RVV.Outcome Measures 
                  The primary outcomes were AGE-related office visits, telephone calls, and episodes (composite outcome consisting of all visits and calls within a 10-day period).Results 
                  Rates of AGE visits in the 2 rotavirus seasons following the introduction of RVV steadily decreased from 3.0 AGE visits per 100 total office visits in the 2005 season to 1.8 in the 2008 season. In 2007, vaccinations were administered to 9351 of 13 951 vaccine-eligible children (67.0%), and in 2008, they were administered to 9958 of 10 728 (92.8%). Among RVV-immunized children in 2007, AGE calls and episodes were significantly reduced with vaccine effectiveness of 53% and 46%, respectively. No significant difference was seen between RVV-immunized and RVV-nonimmunized children for any outcome in 2008.Conclusions 
                  Rotavirus vaccine was associated with a significant reduction in outpatient AGE calls and episodes among immunized children in our network in 2007. Despite a reduction in winter AGE rates in the network, no difference was detected between RVV-immunized and RVV-nonimmunized children for any outcome in 2008. Further study is needed to understand the lack of vaccine effect in 2008.