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The June issue of the ARCHIVES features a "Pathologic Case of the Month" on erythropoietic protoporphyria and outlines the progressive damage that can be caused by an overabundance of type IV collagen.1 Repeated episodes lead to fibrogenic changes in the skin and, sometimes, to cirrhosis in the liver. I would like to ask whether this disease is mostly inflammation involving primarily the fibrosis limb of inflammation?
I would also like to suggest there may be a link to another disease that features type IV collagen abnormalities, ie, Alport syndrome. In that condition, basement membranes in glomeruli and other structures are abnormal and there may be progressive glomerular incapacity. Might this condition also involve recurrent bouts of remote inflammation and consequent fibrogenesis?
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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