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September 1990, Vol 144, No. 9 >
Article | September 1990

Clinical Utility of Cycle Exercise for the Physiologic Assessment of Growth Hormone Release in Children FREE

Richard L. Seip, PhD; Arthur Weltman, PhD; David Goodman; Alan D. Rogol, MD, PhD
[+] Author Affiliations

Accepted for publication January 20, 1990.

Reprint requests to Department of Pediatrics, University of Virginia Health Sciences Center, MR-4/Room 3037, Charlottesville, VA 22908 (Dr Rogol).


Arch Pediatr Adolesc Med. 1990;144(9):998-1000. doi:10.1001/archpedi.1990.02150330058021
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• The clinical utility of exercise as a stimulus for the physiologic assessment of growth hormone (GH) deficiency was examined in healthy children. In response to exercise tests performed on different days, serum GH concentrations exceeded 7 μg/L on both days in 9 of 10 children. Although there is variation in this method of physiologic testing in the response of serum GH concentration (significant mean differences in GH peak values, 27.1 vs 19.8 μg/L for the two tests), the exercise test proved clinically valid in that diagnostic levels of GH were exceeded on both days 90% of the time. We conclude that this exercise evaluation protocol has clinical utility for the assessment of GH deficiency in children.

(AJDC. 1990;144:998-1000)

REFERENCES

1 +
Blizzard RM.  Incidence of growth hormone deficiency: does anyone really know? Growth Genet Horm . 1985;;1:4.
2 +
Vimpani GV, Vimpani AF, Lidgard GP, Cameron EHD, Farquhar JW.  Prevalence of severe growth hormone deficiency . Br Med J . 1977;;2:427-430.
3 +
Buckler JMH.  Plasma growth hormone response to exercise as a diagnostic aid . Arch Dis Child . 1973;;48:565-567.
4 +
Lacey KA, Hewison K, Parkin JM.  Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child . 1973;;48:508-512.
5 +
De San Lazaro C, Parkin JM, Turner SJ.  Treadmill exercise in short children . Arch Dis Child . 1984;;59:1179-1181.
6 +
Nicoll AG, Smail PJ, Forsyth CC.  Exercise test for growth hormone deficiency . Arch Dis Child . 1984;;59:1177-1178.
7 +
Parkin JM.  Exercise as test of growth hormone secretion . Acta Endocrinol Suppl . 1986;; 279:47-50.
8 +
Bar-Or O. Pediatric Sports Medicine for the Practitioner . New York, NY: Springer-Verlag; 1983;:306.
9 +
Daniel WD. Biostatistics: A Foundation for Analysis in the Health Sciences . New York, NY: John Wiley & Sons Inc; 1983;.
10 +
Frasier SD.  A review of growth hormone stimulation tests in children . Pediatrics . 1974;; 53:929-937.
11 +
Raynaud J, Capderou A, Martineaud J-P, Bordachar J, Durand J.  Intersubject variability in growth hormone time course during different types of work . J Appl Physiol . 1983;;55:1682-1687.
12 +
Wahrenberg WB, Ling N, Bohlen P, Esch F, Brazeau P, Guillemin R.  Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion . Biochem Biophys Res Commun . 1982;;105:562-567.
13 +
Tannnenbaum GS, Ling N.  The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion . Endocrinology . 1984;;115: 1952-1957.
14 +
Vance ML, Borges JLC, Kaiser DL, et al.  Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man . J Clin Endocrinol Metab . 1984;;58:838-844.
15 +
Martha PM Jr, Blizzard RM, Rogol AD.  Atenolol enhances growth hormone release to growth hormone–releasing hormone but fails to alter spontaneous nocturnal growth hormone secretion in boys with constitutional delay of growth . Pediatr Res . 1988;;23:393-397.
16 +
Reiter EO, Morris AH, MacGillivray MH, Weber D.  Variable estimates of serum growth hormone concentrations by different radioassay systems . J Clin Endocrinol Metab . 1988;;66:68-71.

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1 +
Blizzard RM.  Incidence of growth hormone deficiency: does anyone really know? Growth Genet Horm . 1985;;1:4.
2 +
Vimpani GV, Vimpani AF, Lidgard GP, Cameron EHD, Farquhar JW.  Prevalence of severe growth hormone deficiency . Br Med J . 1977;;2:427-430.
3 +
Buckler JMH.  Plasma growth hormone response to exercise as a diagnostic aid . Arch Dis Child . 1973;;48:565-567.
4 +
Lacey KA, Hewison K, Parkin JM.  Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child . 1973;;48:508-512.
5 +
De San Lazaro C, Parkin JM, Turner SJ.  Treadmill exercise in short children . Arch Dis Child . 1984;;59:1179-1181.
6 +
Nicoll AG, Smail PJ, Forsyth CC.  Exercise test for growth hormone deficiency . Arch Dis Child . 1984;;59:1177-1178.
7 +
Parkin JM.  Exercise as test of growth hormone secretion . Acta Endocrinol Suppl . 1986;; 279:47-50.
8 +
Bar-Or O. Pediatric Sports Medicine for the Practitioner . New York, NY: Springer-Verlag; 1983;:306.
9 +
Daniel WD. Biostatistics: A Foundation for Analysis in the Health Sciences . New York, NY: John Wiley & Sons Inc; 1983;.
10 +
Frasier SD.  A review of growth hormone stimulation tests in children . Pediatrics . 1974;; 53:929-937.
11 +
Raynaud J, Capderou A, Martineaud J-P, Bordachar J, Durand J.  Intersubject variability in growth hormone time course during different types of work . J Appl Physiol . 1983;;55:1682-1687.
12 +
Wahrenberg WB, Ling N, Bohlen P, Esch F, Brazeau P, Guillemin R.  Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion . Biochem Biophys Res Commun . 1982;;105:562-567.
13 +
Tannnenbaum GS, Ling N.  The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion . Endocrinology . 1984;;115: 1952-1957.
14 +
Vance ML, Borges JLC, Kaiser DL, et al.  Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man . J Clin Endocrinol Metab . 1984;;58:838-844.
15 +
Martha PM Jr, Blizzard RM, Rogol AD.  Atenolol enhances growth hormone release to growth hormone–releasing hormone but fails to alter spontaneous nocturnal growth hormone secretion in boys with constitutional delay of growth . Pediatr Res . 1988;;23:393-397.
16 +
Reiter EO, Morris AH, MacGillivray MH, Weber D.  Variable estimates of serum growth hormone concentrations by different radioassay systems . J Clin Endocrinol Metab . 1988;;66:68-71.

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