0
October 1984, Vol 138, No. 10 >
Article | October 1984

Random Fecal α1-Antitrypsin Excretion in Children With Intestinal Disorders FREE

Gabriel Dinari, MD; Yoram Rosenbach, MD; Ilan Zahavi, MD; Yaacov Sivan, MD; Menachem Nitzan, MD
[+] Author Affiliations

Reprint requests to Pediatric Gastroenterology Unit, Beilinson Medical Center, Petah Tiqva 49 100, Israel (Dr Dinari).


Arch Pediatr Adolesc Med. 1984;138(10):971-973. doi:10.1001/archpedi.1984.02140480073022
Text Size: A A A
Published online
Article
References
Comments

• Demonstration of excessive enteric protein loss traditionally required the use of labeled macromolecules and prolonged stool collection uncontaminated by urine. α1-Antitrypsin (α1-AT) clearance has recently been used for the demonstration of enteric protein loss, but controversy still exists about the value of determining α1-AT concentration in random stool samples. We have measured α1-AT excretion in random stool samples from children with various gastrointestinal (GI) tract disorders using an immune nephelometric method. Statistically significant elevations in α1-AT concentrations were found in stools from patients with active celiac disease and confirmed PLE, while normal values were demonstrated in patients with irritable bowel and inactive celiac disease. We conclude that determination of α1-AT concentration in random fecal samples is an easy, reproducible screening method for the demonstration of excessive enteric protein loss in various GI tract disorders.

(AJDC 1984;138:971-973)

REFERENCES

1 +
Waldman TA:  Protein-losing enteropathy and kinetic studies of plasma protein metabolism . Semin Nucl Med 1972;;2:251-264.
2 +
Colon AR, Sandberg DH:  Protein-losing enteropathy in children . South Med J 1973;;66: 641-644.
3 +
Sharp HL:  The current status of alpha-1-antitrypsin, a protease inhibitor, in gastrointestinal disease . Gastroenterology 1976;;70: 611-621.
4 +
Crossley JR, Elliott RB:  Simple method for diagnosing protein-losing enteropathies . Br Med J 1977;;1:428-429.
5 +
Thomas DW, Sinatra FR, Merritt RJ:  Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease . Gastroenterology 1981;;80:776-782.
6 +
Florent C, L'Hirondel C, Desmazures C, et al:  Intestinal clearance of alpha-1-antitrypsin: A sensitive method for the detection of protein-losing enteropathy . Gastroenterology 1981;;81: 777-780.
7 +
Bernier JJ, Florent C, Desmazures C, et al:  Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha-1-antitrypsin . Lancet 1978;;2:763-764.
8 +
Hill RF, Herez A, Corey ML, et al:  Fecal clearance of alpha-1-antitrypsin: A reliable measure of enteric protein loss in children . J Pediatr 1981;;99:416-418.
9 +
Maki M, Harmoinen A, Vesikari T, et al:  Faecal excretion of alpha-1-antitrypsin in acute diarrhea . Arch Dis Child 1982;;57:154-155.
10 +
Haeney MR, Fields J, Carter RA, et al:  Is faecal alpha-1-antitrypsin excretion a reliable screening test for protein-losing enteropathy? Lancet 1979;;2:1161-1162.
11 +
Keaney NP, Kelleher J:  Faecal excretion of alpha-1-antitrypsin in protein-losing enteropathy . Lancet 1980;;1:711.
12 +
Lizana J, Hellsing K:  Manual immunonephelometric assay of proteins with the use of polymer enhancement . Clin Chem 1974;;20: 1181-1186.
13 +
Tourtellote WW, Tavolato B, Parker JA, et al:  Cerebrospinal fluid electroimmunodiffusion: An easy, rapid, sensitive, reliable and valid method for the simultaneous determination of immunoglobulin G and albumin . Arch Neurol 1971;;25:345-350.
14 +
Lebenthal E, Branski D:  Childhood celiac disease: A reappraisal . J Pediatr 1981;;98:681-690.
15 +
Bjarnason I, Veall N, Peters JJ:  Is there a primary defect of intestinal permeability in celiac disease? Gastroenterology 1983;;84:1107.
16 +
Ryley HC, Neale L, Brogan TD, et al:  Plasma proteins in meconium from normal infants and from babies with cystic fibrosis . Arch Dis Child 1974;;49:901-904.
17 +
Grill BB, Tinghitello T, Hillemeier C, et al:  Increased intestinal clearance of α1-antitrypsin in patients with α1-antitrypsin deficiency . J Pediatr Gastroenterol Nutr 1983;;2:95-98.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Waldman TA:  Protein-losing enteropathy and kinetic studies of plasma protein metabolism . Semin Nucl Med 1972;;2:251-264.
2 +
Colon AR, Sandberg DH:  Protein-losing enteropathy in children . South Med J 1973;;66: 641-644.
3 +
Sharp HL:  The current status of alpha-1-antitrypsin, a protease inhibitor, in gastrointestinal disease . Gastroenterology 1976;;70: 611-621.
4 +
Crossley JR, Elliott RB:  Simple method for diagnosing protein-losing enteropathies . Br Med J 1977;;1:428-429.
5 +
Thomas DW, Sinatra FR, Merritt RJ:  Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease . Gastroenterology 1981;;80:776-782.
6 +
Florent C, L'Hirondel C, Desmazures C, et al:  Intestinal clearance of alpha-1-antitrypsin: A sensitive method for the detection of protein-losing enteropathy . Gastroenterology 1981;;81: 777-780.
7 +
Bernier JJ, Florent C, Desmazures C, et al:  Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha-1-antitrypsin . Lancet 1978;;2:763-764.
8 +
Hill RF, Herez A, Corey ML, et al:  Fecal clearance of alpha-1-antitrypsin: A reliable measure of enteric protein loss in children . J Pediatr 1981;;99:416-418.
9 +
Maki M, Harmoinen A, Vesikari T, et al:  Faecal excretion of alpha-1-antitrypsin in acute diarrhea . Arch Dis Child 1982;;57:154-155.
10 +
Haeney MR, Fields J, Carter RA, et al:  Is faecal alpha-1-antitrypsin excretion a reliable screening test for protein-losing enteropathy? Lancet 1979;;2:1161-1162.
11 +
Keaney NP, Kelleher J:  Faecal excretion of alpha-1-antitrypsin in protein-losing enteropathy . Lancet 1980;;1:711.
12 +
Lizana J, Hellsing K:  Manual immunonephelometric assay of proteins with the use of polymer enhancement . Clin Chem 1974;;20: 1181-1186.
13 +
Tourtellote WW, Tavolato B, Parker JA, et al:  Cerebrospinal fluid electroimmunodiffusion: An easy, rapid, sensitive, reliable and valid method for the simultaneous determination of immunoglobulin G and albumin . Arch Neurol 1971;;25:345-350.
14 +
Lebenthal E, Branski D:  Childhood celiac disease: A reappraisal . J Pediatr 1981;;98:681-690.
15 +
Bjarnason I, Veall N, Peters JJ:  Is there a primary defect of intestinal permeability in celiac disease? Gastroenterology 1983;;84:1107.
16 +
Ryley HC, Neale L, Brogan TD, et al:  Plasma proteins in meconium from normal infants and from babies with cystic fibrosis . Arch Dis Child 1974;;49:901-904.
17 +
Grill BB, Tinghitello T, Hillemeier C, et al:  Increased intestinal clearance of α1-antitrypsin in patients with α1-antitrypsin deficiency . J Pediatr Gastroenterol Nutr 1983;;2:95-98.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems