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Transient Erythroblastopenia of Childhood: Title and subTitle BreakReview of 17 Cases, Including a Pair of Identical Twins FREE

Richard J. Labotka, MD; Helen S. Maurer, MD; George R. Honig, MD, PhD
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Reprint requests to 2300 Children's Plaza, Chicago, IL 60614 (Dr Labotka).


Arch Pediatr Adolesc Med. 1981;135(10):937-940. doi:10.1001/archpedi.1981.02130340043015
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• Seventeen patients aged 7 to 33 months, including a pair of identical twin girls, came to the Children's Memorial Hospital, Chicago, between January 1975 and December 1979 with transient normocytic anemia and reticulocytopenia. In 16 of the patients, bone marrow aspirates were obtained; 15 showed erythroblastopenia and one showed erythroid hyperplasia indicative of recovery. Except for a cluster of six cases occurring from July to October 1979, no seasonal variation was observed. Unlike patients with congenital hypoplastic anemia, all 17 patients were of normal stature. Other distinguishing features of transient erythroblastopenia of childhood included onset after early infancy, normocytosis, and rapid, spontaneous recovery.

(Am J Dis Child 1981;135:937-940)

REFERENCES

Wranne L, Bonnevier JO, Killander A, et al:  Pure red cell anemia with pro-erythroblast maturation arrest . Scand J Haematol 1970;;7:73-75.
Wranne L:  Transient erythroblastopenia in infancy and childhood . Scand J Haematol 1970;;7:76-81.
Lovric VA:  Anemia and temporary erythroblastopenia in children . Aust Ann Med 1970;;1:34-39.
Betke K, Marti HR, Schlicht I:  Estimation of small percentages of foetal haemoglobins . Nature 1959;;184:1877.
Smith DW: Recognizable Patterns of Human Malformation . Philadelphia, WB Saunders Co, 1970;, pp 453-460.
Shah NR, Wolff JA, Sitarz A:  Transient acquired red blood cell (RBC) aplasia in children without hematologic disease . Pediatr Res 1976;;10:381.
Tillmann W, Prindull G, Schröter W:  Severe anemia due to transient pure red cell aplasia in early childhood . Eur J Pediatr 1976;;123:51-58.
Wang WC, Mentzer WC:  Differentiation of transient erythroblastopenia in childhood from congenital hypoplastic anemia . J Pediatr 1976;;88:784-789.
Wegelius R, Weber TH:  Transient erythroblastopenia in childhood . Acta Paediatr Scand 1978;;67:513-518.
Kubic PT, Warkentin PI, Levitt CJ, et al:  Transient erythroblastopenia of childhood (TEC) occurring in clusters . Pediatr Res 1979;;13:435.
Link MI, Alter BP:  Fetal erythropoiesis in transient erythroblastopenia of childhood . Pediatr Res 1979;;13:435.
Toogood IRG, Speed IE, Cheney KC, et al:  Idiopathic transient normocytic, normochromic anaemia of childhood . Aust Paediatr J 1978;;14:28-33.
Al-Rashid RA:  Idiopathic transient erythroblastopenia of childhood . Am J Pediatr Hematol Oncol 1979;;1:363-367.
Koenig HM, Lightsey AL, Nelson DP, et al:  Immune suppression of erythropoiesis in transient erythroblastopenia of childhood . Blood 1979;;54:742-746.
Alter BP:  Childhood red cell aplasia . Am J Pediatr Hematol Oncol 1980;;2:121-139.
Diamond LK, Wang WC, Alter BP:  Congenital hypoplastic anemia . Adv Pediatr 1976;;22:349-378.
Gasser C:  Aplasia of erythropoiesis . Pediatr Clin North Am 1957;;4:445-468.

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Wranne L, Bonnevier JO, Killander A, et al:  Pure red cell anemia with pro-erythroblast maturation arrest . Scand J Haematol 1970;;7:73-75.
Wranne L:  Transient erythroblastopenia in infancy and childhood . Scand J Haematol 1970;;7:76-81.
Lovric VA:  Anemia and temporary erythroblastopenia in children . Aust Ann Med 1970;;1:34-39.
Betke K, Marti HR, Schlicht I:  Estimation of small percentages of foetal haemoglobins . Nature 1959;;184:1877.
Smith DW: Recognizable Patterns of Human Malformation . Philadelphia, WB Saunders Co, 1970;, pp 453-460.
Shah NR, Wolff JA, Sitarz A:  Transient acquired red blood cell (RBC) aplasia in children without hematologic disease . Pediatr Res 1976;;10:381.
Tillmann W, Prindull G, Schröter W:  Severe anemia due to transient pure red cell aplasia in early childhood . Eur J Pediatr 1976;;123:51-58.
Wang WC, Mentzer WC:  Differentiation of transient erythroblastopenia in childhood from congenital hypoplastic anemia . J Pediatr 1976;;88:784-789.
Wegelius R, Weber TH:  Transient erythroblastopenia in childhood . Acta Paediatr Scand 1978;;67:513-518.
Kubic PT, Warkentin PI, Levitt CJ, et al:  Transient erythroblastopenia of childhood (TEC) occurring in clusters . Pediatr Res 1979;;13:435.
Link MI, Alter BP:  Fetal erythropoiesis in transient erythroblastopenia of childhood . Pediatr Res 1979;;13:435.
Toogood IRG, Speed IE, Cheney KC, et al:  Idiopathic transient normocytic, normochromic anaemia of childhood . Aust Paediatr J 1978;;14:28-33.
Al-Rashid RA:  Idiopathic transient erythroblastopenia of childhood . Am J Pediatr Hematol Oncol 1979;;1:363-367.
Koenig HM, Lightsey AL, Nelson DP, et al:  Immune suppression of erythropoiesis in transient erythroblastopenia of childhood . Blood 1979;;54:742-746.
Alter BP:  Childhood red cell aplasia . Am J Pediatr Hematol Oncol 1980;;2:121-139.
Diamond LK, Wang WC, Alter BP:  Congenital hypoplastic anemia . Adv Pediatr 1976;;22:349-378.
Gasser C:  Aplasia of erythropoiesis . Pediatr Clin North Am 1957;;4:445-468.

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