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Mitogenic Response to Toxocara Antigen and Chemotactic Defect in Visceral Larva Migrans FREE

Kenneth Caldwell, MD; Michael Lobell, MD; Pater F. Coccia, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Minnesota Health Sciences Center, Box 228 Mayo, Minneapolis, MN 55455 (Dr Coccia).


Arch Pediatr Adolesc Med. 1980;134(9):845-847. doi:10.1001/archpedi.1980.02130210029008
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• A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. A marked mitogenic response of her cultured lymphocytes to Toxocara antigen but not to Ascaris antigen was found. A neutrophil chemotactic abnormality to Escherichia coli culture filtrates and zymosan-activated sera was also demonstrated, which partially corrected after she was treated with diethylcarbamazine citrate.

(Am J Dis Child 134:845-847, 1980)

REFERENCES

Huntley CC, Costas MC, Lyerly A:  Visceral larva migrans syndrome: Clinical characteristics and immunodiagnostic studies in 51 patients . Pediatrics 36:523-536, 1965;.
Mok CH:  Visceral larva migrans: A discussion based on review of the literature . Clin Pediatr 7:565-573, 1968;.
Hogarth-Scott RS, Johansson SGO, Bennich H:  Antibodies to Toxocara in the sera of visceral larva migrans patients: The significance of raised levels of IgE . Clin Exp Immunol 5:619-625, 1969;.
Patterson R, Huntley CC, Roberts M, et al:  Visceral larva migrans: Immunoglobulins, precipitating antibodies and detection of IgG and IgM antibodies against Toxocara antigen . Am J Trop Med Hyg 24:465-470, 1975;.
Boyden SV:  The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes . J Exp Med 115:453-466, 1962;.
Hill HR, Quie PG:  Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1:183-187, 1974;.
Bowers TK, Craddock PR, Jacob HS:  Acquired granulocyte abnormality during drug allergic reactions: Possible role of complement activation . Blood 49:3-8, 1977;.
Craddock PR, Fehr J, Jacob HS:  Complement-mediated granulocyte dysfunction in paroxysmal nocturnal hemoglobinuria . Blood 47:931-940, 1976;.
Fontan G:  Defective neutrophil chemotaxis and hyperimmunoglobulinemia E: A reversible defect? Acta Pediatr Scand 65:509-511, 1976;.
Buckley RH, Wray BB, Belmaker EZ:  Extreme hyperimmunoglobulinemia E and undue susceptibility to infection . Pediatrics 49:59-70, 1972;.

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Huntley CC, Costas MC, Lyerly A:  Visceral larva migrans syndrome: Clinical characteristics and immunodiagnostic studies in 51 patients . Pediatrics 36:523-536, 1965;.
Mok CH:  Visceral larva migrans: A discussion based on review of the literature . Clin Pediatr 7:565-573, 1968;.
Hogarth-Scott RS, Johansson SGO, Bennich H:  Antibodies to Toxocara in the sera of visceral larva migrans patients: The significance of raised levels of IgE . Clin Exp Immunol 5:619-625, 1969;.
Patterson R, Huntley CC, Roberts M, et al:  Visceral larva migrans: Immunoglobulins, precipitating antibodies and detection of IgG and IgM antibodies against Toxocara antigen . Am J Trop Med Hyg 24:465-470, 1975;.
Boyden SV:  The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes . J Exp Med 115:453-466, 1962;.
Hill HR, Quie PG:  Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1:183-187, 1974;.
Bowers TK, Craddock PR, Jacob HS:  Acquired granulocyte abnormality during drug allergic reactions: Possible role of complement activation . Blood 49:3-8, 1977;.
Craddock PR, Fehr J, Jacob HS:  Complement-mediated granulocyte dysfunction in paroxysmal nocturnal hemoglobinuria . Blood 47:931-940, 1976;.
Fontan G:  Defective neutrophil chemotaxis and hyperimmunoglobulinemia E: A reversible defect? Acta Pediatr Scand 65:509-511, 1976;.
Buckley RH, Wray BB, Belmaker EZ:  Extreme hyperimmunoglobulinemia E and undue susceptibility to infection . Pediatrics 49:59-70, 1972;.

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