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October 1978, Vol 132, No. 10 >
Article | October 1978

Prolonged Nitroprusside and Intermittent Hemodialysis as Therapy for Intractable Hypertension FREE

Alfredo J. Elberg, MD; Helen M. Gorman, MB, BCh; Rex Baker, MS; A. José Wenger, MD; José Strauss, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Miami School of Medicine, PO Box 520875, Miami, FL 33152 (Dr Strauss).


Arch Pediatr Adolesc Med. 1978;132(10):988-989. doi:10.1001/archpedi.1978.02120350052009
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• Nitroprusside was used with intermittent hemodialysis over a 26-day period in a 6-year-old boy with intractable hypertension. Hemodialysis effectively removed thiocyanate from the blood, thus preventing its accumulation and subsequent toxic manifestations. Prolonged nitroprusside infusion maintained arterial blood pressure at acceptable levels until the patient became responsive to other antihypertensive therapy.

(Am J Dis Child 132:988-989, 1978)

REFERENCES

1 +
Page IH:  Treatment of essential and malignant hypertension . JAMA 147:1311-1318, 1951;.
2 +
Page IH, Corcoran AC, Dustan HP, et al:  Cardiovascular actions of sodium nitroprusside in animals and hypertensive patients . Circulation 11:188-198, 1955;.
3 +
Palmer RF, Lasseter KC:  Sodium nitroprusside . N Engl J Med 292:294-297, 1975;.
4 +
Nickerson M, Ruedy J:  Antihypertensive agents and the drug therapy of hypertension , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, MacMillan & Co Ltd, 1975;, pp 705-726.
5 +
Gordillo-Paniagua G, Velásquez-Jones L, Martini R, et al:  Sodium nitroprusside treatment of severe arterial hypertension in children . J Pediatr 87:799-802, 1975;.
6 +
Luderer JR, Hayes AH Jr, Dubynsky O, et al:  Long-term administration of sodium nitroprusside in childhood . J Pediatr 91:490-491, 1977;.
7 +
Johnson CC:  The actions and toxicity of sodium nitroprusside . Arch Int Pharmacodyn Ther 35:480-496, 1929;.
8 +
Deichmann WB, Gerarde HW: Toxicology of Drugs and Chemicals . New York, Academic Press Inc, 1969;.
9 +
Nourok DS, Glassock RJ, Solomon DH, et al:  Hypothyroidism following prolonged sodium nitroprusside therapy . Am J Med Sci 248:129-138, 1964;.
10 +
Korz R, Mann H:  Thiocyanate metabolism and thyroid function in chronic renal insufficiency . Clin Nephrol 1:307-310, 1973;.
11 +
Pettigrew AR, Fell GS:  Simplified colorimetric determination of thiocyanate in biological fluids and its application to investigation of the toxic amblyopias . Clin Chem 18:996-1000, 1972;.
12 +
Playfair L: On the Nitroprussides: A New Class of Salts . London, RJE Taylor, 1849;.
13 +
Goldstein F, Rieders F:  Conversion of thiocyanate to cyanide by an erythrocytic enzyme . Am J Physiol 173:287-290, 1953;.
14 +
Danzig LE, Kringel AJ:  Use of the artificial kidney in treatment of thiocyanate psychosis . JAMA 158:560-563, 1955;.
15 +
Scheinberg IH, Kowalski HJ:  The binding of thiocyanate to albumin in normal human serum and defibrinated blood with reference to the determination of "thiocyanate space." J Clin Invest 29:475-482, 1950;.
16 +
Vertes V, Cangiano JL, Berman LB, et al:  Hypertension in end-stage renal disease . N Engl J Med 280:978-984, 1969;.

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1 +
Page IH:  Treatment of essential and malignant hypertension . JAMA 147:1311-1318, 1951;.
2 +
Page IH, Corcoran AC, Dustan HP, et al:  Cardiovascular actions of sodium nitroprusside in animals and hypertensive patients . Circulation 11:188-198, 1955;.
3 +
Palmer RF, Lasseter KC:  Sodium nitroprusside . N Engl J Med 292:294-297, 1975;.
4 +
Nickerson M, Ruedy J:  Antihypertensive agents and the drug therapy of hypertension , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, MacMillan & Co Ltd, 1975;, pp 705-726.
5 +
Gordillo-Paniagua G, Velásquez-Jones L, Martini R, et al:  Sodium nitroprusside treatment of severe arterial hypertension in children . J Pediatr 87:799-802, 1975;.
6 +
Luderer JR, Hayes AH Jr, Dubynsky O, et al:  Long-term administration of sodium nitroprusside in childhood . J Pediatr 91:490-491, 1977;.
7 +
Johnson CC:  The actions and toxicity of sodium nitroprusside . Arch Int Pharmacodyn Ther 35:480-496, 1929;.
8 +
Deichmann WB, Gerarde HW: Toxicology of Drugs and Chemicals . New York, Academic Press Inc, 1969;.
9 +
Nourok DS, Glassock RJ, Solomon DH, et al:  Hypothyroidism following prolonged sodium nitroprusside therapy . Am J Med Sci 248:129-138, 1964;.
10 +
Korz R, Mann H:  Thiocyanate metabolism and thyroid function in chronic renal insufficiency . Clin Nephrol 1:307-310, 1973;.
11 +
Pettigrew AR, Fell GS:  Simplified colorimetric determination of thiocyanate in biological fluids and its application to investigation of the toxic amblyopias . Clin Chem 18:996-1000, 1972;.
12 +
Playfair L: On the Nitroprussides: A New Class of Salts . London, RJE Taylor, 1849;.
13 +
Goldstein F, Rieders F:  Conversion of thiocyanate to cyanide by an erythrocytic enzyme . Am J Physiol 173:287-290, 1953;.
14 +
Danzig LE, Kringel AJ:  Use of the artificial kidney in treatment of thiocyanate psychosis . JAMA 158:560-563, 1955;.
15 +
Scheinberg IH, Kowalski HJ:  The binding of thiocyanate to albumin in normal human serum and defibrinated blood with reference to the determination of "thiocyanate space." J Clin Invest 29:475-482, 1950;.
16 +
Vertes V, Cangiano JL, Berman LB, et al:  Hypertension in end-stage renal disease . N Engl J Med 280:978-984, 1969;.

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