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January 1975, Vol 129, No. 1 >
Article | January 1975

Androgen Therapy in an "Excessively" Tall Boy FREE

Rogelio H. A. Ruvalcaba, MD; Diana S. Tattoni, MD; Vincent C. Kelley, MD, PhD
[+] Author Affiliations

Received for publication April 18, 1974; accepted Aug 12.

Reprint requests to Rainier School, Buckley, WA 98321 (Dr. Ruvalcaba).


Arch Pediatr Adolesc Med. 1975;129(1):95-97. doi:10.1001/archpedi.1975.02120380069015
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An "excessively" tall, early pubertal boy was treated with androgen for a period of 33 months. Sexual development and fusion of epiphyses was accelerated with achievement of shorter stature than that predicted prior to therapy. Testicular size did not appear to be impaired by the therapy. Androgen administration in this young boy appeared to be effective in shortening the eventual adult stature.

REFERENCES

1 +
Whitelaw MJ, Foster TN:  Treatment of excessive height in girls: A long-term study . J Pediatr 61:566-570, 1962;.
2 +
Whitelaw MJ, Foster TN, Graham WH:  Estradiol valerate: Its effects on anabolism and skeletal age in the prepubertal girl . J Clin Endocrinol Metab 23:1125-1129, 1963;.
3 +
Wettenhall HNB, Roche AF:  Tall girls assessment and management . Aust Paediatr J 1:210-216, 1964;.
4 +
Greenblatt RB, McDonough PG, Mahesh VB:  Estrogen therapy in inhibition of growth . J Clin Endocrinol Metab 26:1185-1191, 1966;.
5 +
Schoen EJ, Solomon IL, Warner O, et al:  Estrogen treatment of tall girls . Am J Dis Child 125:71-74, 1973;.
6 +
Whitelaw MJ:  Experiences in treating excessive height in girls with cyclic oestradiol valerate: A ten-year survey . Acta Endocrinol 54:473-484, 1967;.
7 +
Bayley H, Gordan GS, Bayer LM, et al:  Attempt to suppress excessive growth in girls by estrogen treatment: Statistical evaluation . J Clin Endocrinol Metab 22:1127-1129, 1962;.
8 +
Whitelaw MJ, Foster TN, Graham WH:  Steroidal induction of the premature growth spurt in prepubertal boys for excessive height . Acta Endocrinol 50:317-320, 1965;.
9 +
Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959;.
10 +
Marshall WA, Tanner JM:  Variations in the pattern of pubertal changes in boys . Arch Dis Child 45:13-23, 1970;.
11 +
Tanner JM, Whitehouse RH, Takaishi M:  Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965 : (Part II) . Arch Dis Child 41:613-635, 1966;.
12 +
Roche AF, Davila GH:  Late adolescent growth in stature . Pediatrics 50:874-880, 1972;.
13 +
Lee PA, Jaffe RB, Midgley AR Jr, et al:  Regulation of human gonadotropins: VIII. Suppression of serum LH and FSH in adult males following exogenous testosterone administration . J Clin Endocrinol Metab 35:636-641, 1972;.
14 +
Kirschner MA, Knorr DWR:  Suppression of androgen and oestrogen production in normal men . Acta Endocrinol 70:342-350, 1972;.
15 +
Arai Y, Masuda S:  Long-lasting effects of prepubertal administration of androgen on male hypothalamic-pituitary gonadal system . Endocrinol Jap 15:375-378, 1968;.
16 +
Meadows AT, Naiman JL, Voldes-Dapena M:  Hepatoma associated with androgen therapy for aplastic anemia . J Pediatr 84:109-110, 1974;.

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1 +
Whitelaw MJ, Foster TN:  Treatment of excessive height in girls: A long-term study . J Pediatr 61:566-570, 1962;.
2 +
Whitelaw MJ, Foster TN, Graham WH:  Estradiol valerate: Its effects on anabolism and skeletal age in the prepubertal girl . J Clin Endocrinol Metab 23:1125-1129, 1963;.
3 +
Wettenhall HNB, Roche AF:  Tall girls assessment and management . Aust Paediatr J 1:210-216, 1964;.
4 +
Greenblatt RB, McDonough PG, Mahesh VB:  Estrogen therapy in inhibition of growth . J Clin Endocrinol Metab 26:1185-1191, 1966;.
5 +
Schoen EJ, Solomon IL, Warner O, et al:  Estrogen treatment of tall girls . Am J Dis Child 125:71-74, 1973;.
6 +
Whitelaw MJ:  Experiences in treating excessive height in girls with cyclic oestradiol valerate: A ten-year survey . Acta Endocrinol 54:473-484, 1967;.
7 +
Bayley H, Gordan GS, Bayer LM, et al:  Attempt to suppress excessive growth in girls by estrogen treatment: Statistical evaluation . J Clin Endocrinol Metab 22:1127-1129, 1962;.
8 +
Whitelaw MJ, Foster TN, Graham WH:  Steroidal induction of the premature growth spurt in prepubertal boys for excessive height . Acta Endocrinol 50:317-320, 1965;.
9 +
Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959;.
10 +
Marshall WA, Tanner JM:  Variations in the pattern of pubertal changes in boys . Arch Dis Child 45:13-23, 1970;.
11 +
Tanner JM, Whitehouse RH, Takaishi M:  Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965 : (Part II) . Arch Dis Child 41:613-635, 1966;.
12 +
Roche AF, Davila GH:  Late adolescent growth in stature . Pediatrics 50:874-880, 1972;.
13 +
Lee PA, Jaffe RB, Midgley AR Jr, et al:  Regulation of human gonadotropins: VIII. Suppression of serum LH and FSH in adult males following exogenous testosterone administration . J Clin Endocrinol Metab 35:636-641, 1972;.
14 +
Kirschner MA, Knorr DWR:  Suppression of androgen and oestrogen production in normal men . Acta Endocrinol 70:342-350, 1972;.
15 +
Arai Y, Masuda S:  Long-lasting effects of prepubertal administration of androgen on male hypothalamic-pituitary gonadal system . Endocrinol Jap 15:375-378, 1968;.
16 +
Meadows AT, Naiman JL, Voldes-Dapena M:  Hepatoma associated with androgen therapy for aplastic anemia . J Pediatr 84:109-110, 1974;.

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