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January 1971, Vol 121, No. 1 >
Article | January 1971

Hemolytic-Uremic-Like Syndrome Following Polycarboxylate Interferon Induction: Title and subTitle BreakTreatment of Dawson's Inclusion-Body Encephalitis FREE

Thomas J. Leavitt, MD; Thomas C. Merigan, MD; John M. Freeman, MD
[+] Author Affiliations

Received for publication Jan 8, 1970.

Reprint requests to 601 N Broadway, Baltimore 21205 (Dr. Freeman).


Arch Pediatr Adolesc Med. 1971;121(1):43-47. doi:10.1001/archpedi.1971.02100120079010
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Comments

Interferon induction by administration of pyran copolymer was utilized in three patients in an attempt to treat chronic measles encephalitis (Dawson's encephalitis). Although the course of the disease was not effected by interferon induction, administration of the drug produced hematologic and urinary alterations resembling the hemolytic-uremic syndrome in one patient. Hematologic studies in two additional patients documented the heparin-like nature of pyran copolymer, and the production of a late hypercoagulable state following its administration.

REFERENCES

1 +
Sever JL, Zeman W:  Serological studies of measles and subacute sclerosing panencephalitis . Neurology 18:95-97, 1968;.
2 +
Baublis JV, Payne FE:  Measles antigen and syncytium formation in brain cell cultures from subacute sclerosing panencephalitis (SSPE) . Proc Soc Exp Biol Med 129:593-597, 1968;.
3 +
Chen TT, Watanabe I, Zeman W, Mealy J Jr:  Subacute Sclerosing Panencephalitis: Propagation of measles virus from brain biopsy in tissue culture . Science 163:1193-1194, 1969;.
4 +
Finter NB (ed) Interferons . Philadelphia, WB Saunders Co, 1966;.
5 +
Freeman JM:  Treatment of subacute sclerosing panencephalitis with 5-bromo-2-deoxyuridine and pyran copolymer . Neurology 18:176-180,1968;.
6 +
Freeman JM:  The clinical spectrum and early diagnosis of Dawson's encephalitis with preliminary notes on treatment . J Pediat 75:590-603, 1969;.
7 +
Gianantonio C, Vitacco M, Mendilaharzu F, et al:  The hemolytic-uremic syndrome . J Pediat 64:478-491, 1964;.
8 +
Freeman JM:  Treatment of Dawson's encephalitis with 5-bromo-2-deoxyuridine: A double blind study . Arch Neurol 21:431-434, 1969;.
9 +
Brit J Haemat 14:105-118, 1968;.
10 +
Davidson and Wells, Clinical Diagnosis by Laboratory Methods . Philadelphia, WB Saunders Co, 1963;.
11 +
Sasaki S:  Toxicity of heparinoids with special reference to the precipitation of fibrinogen . Thromb Diath Haemorrh 12:232-261, 1964;.
12 +
Brain MC, Esterly JR, Beck EA:  Intravascular hemolysis with experimentally produced vascular thrombi . Brit J Haemat 13:868-891, 1967;.
13 +
Rubenberg ML, Regoeczi E, Bull BS, et al:  Microangiopathic haemolytic anemia: The experimental production of hemolysis and red-cell fragmentation by defibrination in vivo . Brit J Haemat 14:627-642, 1968;.
14 +
Regelson W: Prevention and treatment of friend leukemia virus infection by interferon inducing synthetic polymers, in Proceedings of the International Symposium on Atherosclerosis and Reticuloendothelial Systems. New York, Academic Press, 1967.
15 +
Merigan TC:  Induction of circulating interferon by synthetic anionic polymers of known composition . Nature 214:416-417, 1967;.
16 +
Merigan TC,  Regelson W: Interferon induction in man by a synthetic polyanion of defined composition . New Eng J Med 277:1283-1287, 1969;.
17 +
Merigan TC, Finklestein MS:  Interferonstimulating and in-vivo antiviral effects of various synthetic anionic polymers . Virology 35:363-374, 1968;.
18 +
Bausek G, and Merigan TC:  Cell interaction with a synthetic polynucleotide and interferon production in vitro . Virology 39:491-498, 1969;.
19 +
DeClercq E, Eckstein F, Merigan TC:  Interferon induction increased through chemical modification of a synthetic polyribonucleotide . Science 165:1137-1139, 1969;.
20 +
Evensen SA, Jeremic M, Hjort PF:  Intravascular coagulation with generalized Schwartzman reaction induced by a heparin like anticoagulant . Thromb Diath Haemorrh 18:24-39, 1967;.
21 +
Rabiner SF, Friedman LH: Role of intravascular haemolysis and the reticuloendothelial system in the production of a hypercoagulable state.
22 +
Merigan TC, Gregory DF, Petralli JK:  Properties of human interferon prepared in vitro and in vivo . Virology 29:515-522, 1966;.

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1 +
Sever JL, Zeman W:  Serological studies of measles and subacute sclerosing panencephalitis . Neurology 18:95-97, 1968;.
2 +
Baublis JV, Payne FE:  Measles antigen and syncytium formation in brain cell cultures from subacute sclerosing panencephalitis (SSPE) . Proc Soc Exp Biol Med 129:593-597, 1968;.
3 +
Chen TT, Watanabe I, Zeman W, Mealy J Jr:  Subacute Sclerosing Panencephalitis: Propagation of measles virus from brain biopsy in tissue culture . Science 163:1193-1194, 1969;.
4 +
Finter NB (ed) Interferons . Philadelphia, WB Saunders Co, 1966;.
5 +
Freeman JM:  Treatment of subacute sclerosing panencephalitis with 5-bromo-2-deoxyuridine and pyran copolymer . Neurology 18:176-180,1968;.
6 +
Freeman JM:  The clinical spectrum and early diagnosis of Dawson's encephalitis with preliminary notes on treatment . J Pediat 75:590-603, 1969;.
7 +
Gianantonio C, Vitacco M, Mendilaharzu F, et al:  The hemolytic-uremic syndrome . J Pediat 64:478-491, 1964;.
8 +
Freeman JM:  Treatment of Dawson's encephalitis with 5-bromo-2-deoxyuridine: A double blind study . Arch Neurol 21:431-434, 1969;.
9 +
Brit J Haemat 14:105-118, 1968;.
10 +
Davidson and Wells, Clinical Diagnosis by Laboratory Methods . Philadelphia, WB Saunders Co, 1963;.
11 +
Sasaki S:  Toxicity of heparinoids with special reference to the precipitation of fibrinogen . Thromb Diath Haemorrh 12:232-261, 1964;.
12 +
Brain MC, Esterly JR, Beck EA:  Intravascular hemolysis with experimentally produced vascular thrombi . Brit J Haemat 13:868-891, 1967;.
13 +
Rubenberg ML, Regoeczi E, Bull BS, et al:  Microangiopathic haemolytic anemia: The experimental production of hemolysis and red-cell fragmentation by defibrination in vivo . Brit J Haemat 14:627-642, 1968;.
14 +
Regelson W: Prevention and treatment of friend leukemia virus infection by interferon inducing synthetic polymers, in Proceedings of the International Symposium on Atherosclerosis and Reticuloendothelial Systems. New York, Academic Press, 1967.
15 +
Merigan TC:  Induction of circulating interferon by synthetic anionic polymers of known composition . Nature 214:416-417, 1967;.
16 +
Merigan TC,  Regelson W: Interferon induction in man by a synthetic polyanion of defined composition . New Eng J Med 277:1283-1287, 1969;.
17 +
Merigan TC, Finklestein MS:  Interferonstimulating and in-vivo antiviral effects of various synthetic anionic polymers . Virology 35:363-374, 1968;.
18 +
Bausek G, and Merigan TC:  Cell interaction with a synthetic polynucleotide and interferon production in vitro . Virology 39:491-498, 1969;.
19 +
DeClercq E, Eckstein F, Merigan TC:  Interferon induction increased through chemical modification of a synthetic polyribonucleotide . Science 165:1137-1139, 1969;.
20 +
Evensen SA, Jeremic M, Hjort PF:  Intravascular coagulation with generalized Schwartzman reaction induced by a heparin like anticoagulant . Thromb Diath Haemorrh 18:24-39, 1967;.
21 +
Rabiner SF, Friedman LH: Role of intravascular haemolysis and the reticuloendothelial system in the production of a hypercoagulable state.
22 +
Merigan TC, Gregory DF, Petralli JK:  Properties of human interferon prepared in vitro and in vivo . Virology 29:515-522, 1966;.

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