Poor clinician adherence to prescribing guidelines is a common barrier in health care delivery, including care of patients with cystic fibrosis (CF). In this study, McPhail et al evaluate a generally applicable model to improve adherence to prescribing guidelines. The goal of the intervention was to shift the clinician-family relationship from a relationship in which the clinician made treatment recommendations to the family and was solely responsible for prescribing guidelines to a relationship in which the family advocated for guideline-recommended therapies from their CF clinician. At the start of the project, only 62% of appropriate medications for 134 patients with CF were prescribed. After 3 months of the project, the rate of clinical adherence to prescribing guidelines increased to 87%, and these improvements were maintained during the 21 months of follow-up.