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Article |

The Natural History of Pityriasis Rosea in Black American Children:  How Correct Is the “Classic” Description? FREE

Ahdi Amer, MD; Howard Fischer, MD; Xiaoming Li, PhD
[+] Author Affiliations

Author Affiliations: The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit.


Arch Pediatr Adolesc Med. 2007;161(5):503-506. doi:10.1001/archpedi.161.4.356.
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Published online

Objectives  To delineate the natural history of pityriasis rosea in black children and to compare our findings with those of the American, European, and African literature on pityriasis rosea. Textbook and journal article descriptions of pityriasis rosea usually offer information about the presentation and clinical course of this condition in white patients.

Design  Prospective observational study.

Setting  The general pediatric clinic, adolescent clinic, and emergency department of Children's Hospital of Michigan, Detroit, from June 2003 through May 2005.

Patients  We followed up 50 black children with pityriasis rosea from the time of diagnosis through follow-up visits at 1, 2, and 4 weeks. Detailed observations were made and digital photographs taken at each visit.

Main Outcome Measures  Duration of illness and pigmentary sequelae.

Results  Similarities with the medical literature were found regarding season of onset and prevalence of pruritus and of a herald patch. Our patients had more frequent facial involvement (30%) and more scalp lesions (8%) than usually described in white populations. One third had papular lesions. The disease resolved in nearly one half of patients within 2 weeks. Residual hyperpigmentation was seen in 48% of patients. Hypopigmentation developed in 29% of patients with purely papular or papulovesicular lesions.

Conclusions  Pityriasis rosea in black children differs in several ways from textbook descriptions. Physicians may use this information to better counsel patients about the course and potential sequelae of this condition.

Figures in this Article

Pityriasis rosea (PR) is a self-limited inflammatory condition of the skin that mostly affects healthy children and adolescents. Typically, it is characterized by the appearance of a herald patch, which is a solitary, oval, scaly lesion that slowly expands, reaching several centimeters in diameter. Within 2 to 21 days, secondary lesions appear and continue to erupt in crops over the next 10 to 21 days and may persist for 4 to 10 weeks. They are round to oval, 5- to 10-mm maculopapules with an elevated scaly border found on the trunk and, less commonly, the extremities.1

We searched the literature for descriptions of PR in black American children and could not find any specific work that addressed the disease characteristics in this group. However, we found several reports from Africa describing the clinical and epidemiological presentations of PR in African children and adults.2,3

This study describes the clinical characteristics of PR in 50 black American children. We highlight the similarities and differences PR has in this patient population as compared with the “usual” description given in the medical literature.

Patients in the study participated in a double-blind, placebo-controlled, prospective study of the efficacy of azithromycin in the treatment of PR.4 Patients between 2 and 18 years of age with a diagnosis of PR were recruited from the general pediatric clinic, adolescent clinic, and emergency department of Children's Hospital of Michigan. Patients had the diagnosis of PR made by 2 of us (A.A. and H.F., both physicians with a total of 45 years' experience practicing pediatrics) in about 80% of cases and by 1 of us (A.A., a physician) and another experienced pediatrician in the remainder. Diagnosis was based on characteristic PR features.1,5 If we did not agree on the diagnosis of PR, the patient was not eligible for study enrollment.

Patient data were collected at the time of the diagnosis on standardized forms. These data included age, sex, race, presence and location of the herald patch, duration of lesions, number of lesions, types and distribution of lesions, presence of pruritus, preceding upper respiratory tract infection, treatments used before the diagnosis, and history of PR exposure. Digital photographs were taken of all lesions when the patients were enrolled and at all follow-up visits.

Patients were seen for follow-up at 1, 2, and 4 weeks after enrolling in the study. Standardized data collection at each follow-up visit included change in lesion numbers and size, presence of pruritus, medication adverse effects, use of other treatments, and the presence of pigmentary changes. As in the diagnostic visit, the patient was evaluated at each follow-up visit by 2 of us (A.A. and H.F., both physicians) in most cases and by 2 physicians in all cases. Digital photographs were again taken. Patients were monetarily compensated for attending follow-up visits. This study was approved by the Wayne State University Human Investigation Committee. Informed consent was obtained from the parent accompanying the child.

Of the 50 patients with PR, there were 18 boys and 32 girls. The peak incidence of cases was in April and May (Figure 1). Pruritus was present in 90% of patients (Table 1). A herald patch was seen in 88% (Figure 2). We did not observe erythema in the lesions of any patient. In the patients who had scaling of their lesions, this was not a subtle finding.

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Figure 1.

Incidence of pityriasis rosea cases by month.

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Figure 2.

Extensive papular pityriasis rosea. Herald patch on right shoulder; classic Christmas-tree distribution.

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Table Graphic Jump LocationTable 1. Findings in 50 Cases of PR in Black Children Compared With the PR Literature

Nearly two thirds of patients had the usually described or “classic” papulosquamous lesions, one third had purely papular lesions (Figure 2), and 4% had papulovesicular lesions. Lesions involved the trunk in all patients, the neck in 44%, the face in 30% (Figure 3), arms and forearms in 60%, thighs and legs in 54%, the pelvis or groin in 12%, and the scalp in 8%. No oral lesions were seen.

Place holder to copy figure label and caption
Figure 3.

Pityriasis rosea with face and neck involvement.

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Almost one third (30%) of patients had between 200 to 300 or more lesions. Twenty-two percent had fewer than 50 lesions. Of patients with more than 200 lesions, 80% had papular or papulovesicular lesions. The correlation between greater lesion numbers and the presence of papular (and papulovesicular) lesions was highly statistically significant (χ² = 17.68; P = .007) (Table 2).

Table Graphic Jump LocationTable 2. Number of Lesions vs Type of Lesion*

Postinflammatory pigmentary changes occurred in 31 patients (62%). Hyperpigmentation (Figure 4) developed in 48% of patients and hypopigmentation (Figure 5), in 14%. Some patients had both hyperpigmentation and hypopigmentation. The presence of residual pigmentation changes (and of pruritus) was not correlated with the number of lesions. Hyperpigmentation did not reflect lesion type, but hypopigmentation was significantly associated with the presence of papular or papulovesicular lesions (Table 3).

Place holder to copy figure label and caption
Figure 4.

Pityriasis rosea with widespread hyperpigmentation of trunk and arm.

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Figure 5.

Pityriasis rosea with widespread hypopigmentation of face and scalp.

Graphic Jump Location
Table Graphic Jump LocationTable 3. Presence of Pruritus and Pigmentary Changes by Lesion Type

Nearly one half of patients had resolution of disease activity (no new lesions, resolution of existing lesions) within 2 weeks of onset. Only 20% of patients had active disease lasting more than 4 weeks. The presence of illness in close contact with a patient is referred to as disease concurrence. Two of our patients were household contacts of an individual with PR (concurrence rate of 4%). Another patient was reported by the parent to have had an episode of PR in the past (disease recurrence of 2%).

This descriptive study of 50 black children with PR showed that there are some similarities between the epidemiological and clinical findings of PR in this group compared with the standard descriptions of PR in the medical literature, as well as some differences that are alluded to but were heretofore not quantified. We will first point out the similarities and then describe the differences. These differences have prognostic importance and may enable physicians to better counsel patients as to the course and outcome of PR.

The peak incidence that we saw in April and May has been described in the literature.6 Pruritus has been reported in 25% to 94% of patients.6,7 Our finding of pruritus in 90% of patients fits into this broad range. Similarly, the 88% prevalence of a herald patch in our patients is within the range of 12% to 94% reported in the literature.8

Others have also described the lack of erythema or rosy color in black patients' lesions,13 as well as the greater visibility of scaling in dark-skinned individuals.14 Our household concurrence rate of 4% (2 patients) for PR is within the 1% to 4.6% range that has been described, and our 2% recurrence rate is compatible with the reported 1.4% to 2.8% range.12

What follows is a discussion of how our findings differ from the PR literature or elaborate on assertions made by some authors. A standard American pediatric dermatology textbook states that “occasionally” PR lesions may be predominantly round popular lesions.1 Reports from Nigeria9 and Uganda2 describe papular lesions in 13% and 22% of patients, respectively. Papular lesions were seen in 34% of our patients, a rate similar to that seen in Africa.

Lesion distribution in our patients had some features that are also found in the literature describing African patients. The pediatric dermatology textbook1 states that the scalp is spared from PR lesions. In African patients with PR, the scalp is involved in 3% to 24% of individuals.2,9 Eight percent of our patients had scalp lesions. Facial lesions were seen in 30% of patients in our study and 47% of patients in 1 African study.2 In the United States, 15% of patients have facial lesions.1

We did not find any literature describing the number of lesions in PR. As stated in the “Results” section, there is a strong correlation between having 200 or more lesions and having lesions with a papular or papulovesicular morphology. A Swedish study of PR found residual hyperpigmentation in 13% of patients and hypopigmentation in 17%.11 In Uganda, 20% of patients had hyperpigmentation and 8% had hypopigmentation after having had PR.2 Nearly one half of our patients had residual hyperpigmentation and 14% had hypopigmentation. The risk for hypopigmentation rose significantly if the patient had papular lesions. Hypopigmentation developed in 29% of patients with papular lesions and in both patients with papulovesicular lesions. This high rate of postinflammatory hypopigmentation as a function of lesion morphology has not been previously quantified. Hypopigmentation, especially on the face (30% of our patients had facial lesions), may represent a serious cosmetic problem for dark-skinned individuals. Physicians should be aware of this possible outcome.

Finally, active lesions resolved in half of our patients within 2 weeks and in 76% within 4 weeks. The studies on African patients did not discuss duration of disease. In Sweden, 43% of patients had resolution within 3 weeks and 84%, within 6 weeks.11

Nearly all of our patients had pruritus. Scratching of lesions may lead to secondary infection and scarring. It would seem reasonable to offer patients relief from their pruritus and to prevent nonpigmentary sequelae by the use of systemic antihistamines, mild topical steroids, or both.

In summary, PR in black American children may involve the scalp and face, is often extensive and papular, may resolve rapidly, and leaves residual pigmentary changes in a majority. These findings may allow physicians to more accurately advise patients when they have PR. Effective treatment still eludes us.4

Correspondence: Ahdi Amer, MD, Division of Ambulatory Pediatrics and Adolescent Medicine, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201 (aamer@med.wayne.edu).

Accepted for Publication: November 16, 2006.

Author Contributions:Study concept and design: Amer and Fischer. Acquisition of data: Amer and Fischer. Analysis and interpretation of data: Amer, Fischer, and Li. Drafting of the manuscript: Amer and Fischer. Critical revision of the manuscript for important intellectual content: Amer, Fischer, and Li. Statistical analysis: Li. Study supervision: Amer and Fischer.

Financial Disclosure: None reported.

Paller  ASMancini  AJ Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders in Childhood and Adolescence. 3rd ed. Philadelphia, Pa Elsevier Saunders2006;
Vollum  DI Pityriasis rosea in the African. Trans St Johns Hosp Dermatol Soc 1973;59269- 271
PubMed
Traore  AKursaga-Some  NNiamba  PBarro  FSanou  IDrabo  YJ Pityriasis rosea in secondary schools in Ouagadougou, Burkina Faso. Ann Dermatol Venereol 2001;128605- 609
PubMed
Amer  AFischer  H Azithromycin does not cure pityriasis rosea. Pediatrics 2006;1171702- 1705
PubMed
Chuh  AA Diagnostic criteria for pityriasis rosea: a prospective case control study for assessment of validity. J Eur Acad Dermatol Venereol 2003;17101- 103
PubMed
Cheong  WKWong  KS An epidemiological study of pityriasis rosea in Middle Road Hospital. Singapore Med J 1989;3060- 62
PubMed
Stulberg  DLWolfrey  J Pityriasis rosea. Am Fam Physician 2004;6987- 92, 94
PubMed
González  LMAllen  RJanniger  CKSchwartz  R Pityriasis rosea: an important papulosquamous disorder. Int J Dermatol 2005;44757- 764
PubMed
Jacyk  WK Pityriasis rosea in Nigerians. Int J Dermatol 1980;19397- 399
PubMed
Olumide  Y Pityriasis rosea in Lagos. Int J Dermatol 1987;26234- 236
PubMed
Bjornberg  AHellgren  L Pityriasis rosea: a statistical, clinical, and laboratory investigation of 826 patients and matched healthy controls. Acta Derm Venereol Suppl (Stockh) 1962;42(suppl 50)1- 68
PubMed
Chuang  TYIlstrup  DMPerry  HOKurland  LT Pityriasis rosea in Rochester, Minnesota, 1969 to 1978. J Am Acad Dermatol 1982;780- 89
PubMed
Johnson  BLMoy  RLWhite  GM Ethnic Skin: Medical and Surgical.  St Louis, Mo Mosby Inc1998;
Bigby  MEDavid  AKBrown  AE Recognition and Management of Skin Diseases in People of Color.  Boston, Mass Harvard School of Public Health1994;

Figures

Place holder to copy figure label and caption
Figure 1.

Incidence of pityriasis rosea cases by month.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Extensive papular pityriasis rosea. Herald patch on right shoulder; classic Christmas-tree distribution.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Pityriasis rosea with face and neck involvement.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Pityriasis rosea with widespread hyperpigmentation of trunk and arm.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 5.

Pityriasis rosea with widespread hypopigmentation of face and scalp.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Findings in 50 Cases of PR in Black Children Compared With the PR Literature
Table Graphic Jump LocationTable 2. Number of Lesions vs Type of Lesion*
Table Graphic Jump LocationTable 3. Presence of Pruritus and Pigmentary Changes by Lesion Type

References

Paller  ASMancini  AJ Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders in Childhood and Adolescence. 3rd ed. Philadelphia, Pa Elsevier Saunders2006;
Vollum  DI Pityriasis rosea in the African. Trans St Johns Hosp Dermatol Soc 1973;59269- 271
PubMed
Traore  AKursaga-Some  NNiamba  PBarro  FSanou  IDrabo  YJ Pityriasis rosea in secondary schools in Ouagadougou, Burkina Faso. Ann Dermatol Venereol 2001;128605- 609
PubMed
Amer  AFischer  H Azithromycin does not cure pityriasis rosea. Pediatrics 2006;1171702- 1705
PubMed
Chuh  AA Diagnostic criteria for pityriasis rosea: a prospective case control study for assessment of validity. J Eur Acad Dermatol Venereol 2003;17101- 103
PubMed
Cheong  WKWong  KS An epidemiological study of pityriasis rosea in Middle Road Hospital. Singapore Med J 1989;3060- 62
PubMed
Stulberg  DLWolfrey  J Pityriasis rosea. Am Fam Physician 2004;6987- 92, 94
PubMed
González  LMAllen  RJanniger  CKSchwartz  R Pityriasis rosea: an important papulosquamous disorder. Int J Dermatol 2005;44757- 764
PubMed
Jacyk  WK Pityriasis rosea in Nigerians. Int J Dermatol 1980;19397- 399
PubMed
Olumide  Y Pityriasis rosea in Lagos. Int J Dermatol 1987;26234- 236
PubMed
Bjornberg  AHellgren  L Pityriasis rosea: a statistical, clinical, and laboratory investigation of 826 patients and matched healthy controls. Acta Derm Venereol Suppl (Stockh) 1962;42(suppl 50)1- 68
PubMed
Chuang  TYIlstrup  DMPerry  HOKurland  LT Pityriasis rosea in Rochester, Minnesota, 1969 to 1978. J Am Acad Dermatol 1982;780- 89
PubMed
Johnson  BLMoy  RLWhite  GM Ethnic Skin: Medical and Surgical.  St Louis, Mo Mosby Inc1998;
Bigby  MEDavid  AKBrown  AE Recognition and Management of Skin Diseases in People of Color.  Boston, Mass Harvard School of Public Health1994;

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