Archives of Pediatrics and Adolescent Medicine will devote the May 2005 issue to studies on the effectiveness of office-based practice. We are interested in studies on all aspects of practice. Individual components of health supervision and health promotion practices need further examination to determine how physicians, and patients, should best use their time and resources. Our interest also extends to disease management in the outpatient setting. Many clinical practice guidelines have been developed, but the extent of their use by physicians is unknown, and, more importantly, their utility in aiding disease management is largely unproven. Variations in care for most problems are great, but how this variation is related to outcomes has largely been examined only for inpatient care. We are interested in studies across the whole pediatric age spectrum, including high school– and college-aged youth. We seek to publish studies that are most able to provide a clear answer to the question asked. Manuscripts received by October 1, 2004, will have the greatest chance of being included in this special issue of ARCHIVES. We have found that papers published in our special theme issues often receive a great deal of attention, as does the issue as a whole.