0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Randomized, Double-blind, Placebo-Controlled Trial of 2 Dosages of Sustained-Release Bupropion for Adolescent Smoking Cessation FREE

Myra L. Muramoto, MD, MPH; Scott J. Leischow, PhD; Duane Sherrill, PhD; Eva Matthews, MPH; Louise J. Strayer, BSc, RN, MSc
[+] Author Affiliations

Author Affiliations: Department of Family and Community Medicine, The University of Arizona College of Medicine (Drs Muramoto and Leischow and Ms Matthews); Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, The University of Arizona (Drs Muramoto and Sherrill); and Department of Psychology, University of Arizona (Ms Strayer), Tucson.

*
Co–first authors.


Arch Pediatr Adolesc Med. 2007;161(11):1068-1074. doi:10.1001/archpedi.161.11.1068.
Text Size: A A A
Published online

Objective  To assess the safety and efficacy of sustained-release bupropion hydrochloride for adolescent smoking cessation.

Design  Prospective, randomized, double-blind, placebo-controlled, dose-ranging trial.

Setting  Metropolitan areas of Tucson and Phoenix, Arizona.

Participants  Adolescents (N = 312) recruited through media and various community venues from March 1, 1999, through December 31, 2002, who were aged 14 to 17 years, smoked 6 or more cigarettes per day, had an exhaled carbon monoxide level of 10 ppm or greater, had at least 2 previous quit attempts, and had no other current major psychiatric diagnosis.

Intervention  Sustained-release bupropion hydrochloride, 150 mg/d (n = 105) or 300 mg/d (n = 104), or placebo (n = 103) for 6 weeks, plus weekly brief individual counseling. Subjects were followed up at 12 weeks (by telephone call) and 26 weeks.

Main Outcome Measure  Confirmed 7-day point prevalence abstinence at 6 weeks and 30-day prolonged abstinence (carbon monoxide level < 10 ppm at each visit; urinary cotinine level ≤ 50 μg/L at weeks 2 and 6).

Results  Cotinine-confirmed 7-day point prevalence abstinence rates at 6 weeks were as follows: placebo, 5.6%; 150 mg, 10.7%; and 300 mg, 14.5% (P = .03, 300 mg vs placebo). At 26 weeks, confirmed point prevalence abstinence rates were as follows: placebo, 10.3%; 150 mg, 3.1%; and 300 mg, 13.9% (P = .049). During treatment, confirmed point prevalence rates were significantly higher for 300 mg than placebo at every week except week 4.

Conclusions  Sustained-release bupropion hydrochloride, 300 mg/d, plus brief counseling demonstrated short-term efficacy for adolescent smoking cessation. Abstinence rates were lower than those reported for adults, with rapid relapse after medication discontinuation.

Trial Registration  clinicaltrials.gov Identifier: NCT00344695

Figures in this Article

Smoking among adolescents remains a considerable public health challenge. An estimated 23.0% of high school students in the United States currently smoke cigarettes.1 Most adult long-term smokers initiated smoking in adolescence, suggesting that many adolescent smokers will go on to become long-term smokers.2,3

Evidence suggests that adolescent smokers experience symptoms of tobacco dependence sooner after initiation and at lower levels of smoking than previously thought. One study found that 95% of adolescent smokers reported tobacco dependence symptoms when smoking fewer than 10 cigarettes per day.4 Many youths are not able to quit smoking on their own. The 2000 National Youth Tobacco Survey found that, among current middle school smokers, 59.5% have tried to quit in the past 12 months and 55.0% want to quit.5 Among current high school smokers, 59.3% have tried to quit in the past 12 months and 61.0% want to quit.5 Other studies estimate that only about 4% of all adolescent smokers attempting to quit per year are successful.68

Compared with smoking cessation research in adults, adolescent smoking cessation research is still in its infancy. However, results from most studies published to date have been discouraging. A comprehensive review of adolescent smoking cessation trials showed a mean quit rate at 3-month follow-up of 12% compared with 7% among control groups; however, because of methodologic differences among studies, comparability of outcomes was limited.9

Pharmacotherapy for nicotine withdrawal has greatly advanced treatment of tobacco dependence in adults. Despite growing evidence that nicotine withdrawal symptoms are an important barrier to adolescent smoking cessation,1012 studies of pharmacotherapy for smoking cessation in adolescents are rare.9 Most recently, a randomized controlled trial of nicotine patch and gum demonstrated that the nicotine patch was significantly more effective than placebo at 2 weeks after the initiation of treatment, with prolonged prevalence quit rates of 17.7% and 2.5%, respectively (P = .043).13 These treatment effects were not sustained at 3-month follow-up. Other nicotine patch trials for adolescent smoking cessation have failed to show significant differences among treatment groups.1417

Bupropion hydrochloride, the first nonnicotine medication approved for smoking cessation, was an important advance in adult treatment of tobacco dependence and has been studied in 2 recent cessation trials for adolescents. An open-label feasibility study of sustained-release (SR) bupropion hydrochloride in adolescents with comorbid attention-deficit/hyperactivity disorder (ADHD) and nicotine dependence showed significant decreases in cigarettes smoked (P < .001) and carbon monoxide levels (P = .04) during the course of 6 weeks of treatment (150 mg twice daily), and abstinence rates of 31.25% after 4 weeks of treatment.18 Findings are limited by a small sample size and lack of placebo control, but they support further investigation in a larger controlled trial. The second study, a randomized trial, compared combined nicotine patch and SR bupropion hydrochloride treatment (150 mg/d) with nicotine patch and placebo.19 Abstinence rates between treatment groups were not significantly different at weeks 6 and 26 (23% and 8%, respectively, for patch and active SR bupropion; 28% and 7%, respectively, for patch and placebo); however, a decrease in smoking across groups was observed.

Bupropion has been more widely used in the treatment of attention deficit disorders in children. Notably, youths at greatest risk for developing nicotine dependence also demonstrate ADHD-like characteristics (including sensation-seeking, rebelliousness, and impulsive behaviors).20 Early studies of bupropion in youths were for treatment of ADHD. Two studies21,22 found bupropion comparable to methylphenidate as an effective treatment for ADHD and safe to use in children as young as 6 years. Side effects were minimal and included mild rash, drowsiness, fatigue, and nausea. None of the youths experienced seizures. Thus, given bupropion's demonstrated safety in youths and efficacy for smoking cessation in adults, we undertook a randomized, placebo-controlled study of bupropion for smoking cessation in adolescents.

The objectives of this trial were to evaluate the efficacy and safety of 2 dosages of SR bupropion hydrochloride (150 mg/d and 300 mg/d), when compared with placebo, as an aid to smoking cessation in adolescents. We hypothesized (1) that abstinence rates would be lowest in the placebo group and highest in the 300 mg group and (2) that adverse events would be negligible in all of the treatment groups but lowest in the placebo group and highest in the 300 mg group.

STUDY DESIGN

This study was a prospective, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging phase III clinical trial with a 6-week treatment phase and blinded poststudy follow-up to week 26. The study was approved by the University of Arizona Human Subjects Committee, a certificate of confidentiality was obtained from the National Cancer Institute, and the US Food and Drug Administration granted an investigational new drug number. Written active parental informed consent and youth assent were obtained from all subjects before any study procedures.

STUDY POPULATION

Healthy, smoking adolescents were recruited from the 2 metropolitan areas of Tucson and Phoenix, Arizona, through radio and television advertisements, local tobacco control programs, shopping malls, high schools, flyers posted at teen music clubs and city bus stops, schools, and physician offices. Subjects were screened for inclusion and exclusion criteria by telephone screen, medical history, physical examination, exhaled carbon monoxide (CO) level, and urine pregnancy test (in girls). Subjects were eligible if they were 14 to 17 years of age, smoked at least 6 cigarettes per day, had an exhaled CO level greater than or equal to 10 ppm, had at least 2 previous quit attempts, weighed at least 40.5 kg, were English literate (6th-grade level), and were motivated to quit smoking. Exclusion criteria were current use of tobacco products other than cigarettes or other smoking cessation treatments; history or current diagnosis or treatment of panic disorder, psychosis, bipolar disorder, or eating disorder; substance abuse or dependence (other than nicotine) in the 3 months preceding the study; current clinical depression or ADHD; any psychoactive drug treatment within 4 weeks of the study treatment phase; increased seizure risk (personal or family history of seizure disorder, receiving treatment that increased seizure risk); and significant cardiovascular disease. Girls were excluded for pregnancy (urine pregnancy test), lactation, or unwillingness to use medically acceptable contraception. Only 1 member of a household was allowed to participate in the study concurrently.

INTERVENTION

Active study medication and identical-appearing placebo were prepackaged into 3 sets of identical-appearing blister cards in accordance with a computer-generated randomization list. At the baseline/prequit visit, a research assistant assigned the subject the next treatment number (and associated blister cards) in sequence. Study subjects and researchers remained blind to treatment group assignment throughout the study. To evaluate the success of blinding, subjects were asked to guess their treatment group at the end of treatment (week 6).

Subjects came to the research clinic for a baseline/prequit visit and were randomized to receive SR bupropion hydrochloride (150 mg/d or 300 mg/d) or placebo. Study medication was administered as 1 tablet orally once a day for the first 3 days of treatment, followed by 1 study medication tablet taken twice daily (morning and evening) for the duration of the treatment phase. Subjects attended study visits at the prequit point (when they received counseling to prepare for quitting), on the quit date, and then weekly for 7 weeks (6 weeks of treatment and 1 week after treatment cessation) to assess smoking status, adherence to the medication regimen, and safety. Study visits were conducted at a research clinic or a satellite research clinic site. Follow-up visits occurred at 12 weeks (telephone visit) and 26 weeks after the target quit date and assessed smoking status, use of cessation aids, and adverse events. Figure 1 shows the study visit flow.

Place holder to copy figure label and caption
Figure 1.

Study visit flow diagram. *Clinic visit. †Telephone call.

Graphic Jump Location

At each visit, subjects received brief individual cessation counseling (10 to 20 minutes) standardized to address a series of topics addressing teaching skills related to changing smoking behaviors, eg, identifying social support, identifying motivations and barriers to quitting, recognition of triggers for smoking, management of nicotine craving and withdrawal symptoms, and stress management. The telephone number for the state quit line was provided for additional behavioral support if desired. Subjects who discontinued medication prematurely were encouraged to remain in the study to complete behavioral support and assessments. After the treatment phase, subjects received no further behavioral support. However, subjects could have received behavioral support from other sources. Use of additional cessation aids was queried and recorded at each visit.

SCREENING

Screening included a medical history, physical examination, measurement of vital signs, height, weight, self-identification of race/ethnicity (using classification options provided at intake), tobacco use history, and exhaled CO. A urine pregnancy test was performed on all girls.

BASELINE AND POSTRANDOMIZATION ASSESSMENTS

Smoking history at baseline included age at first cigarette, number of previous quit attempts, and smoking in the past 90 days. Nicotine dependence was assessed with a 7-item modified version of the Fagerström Tolerance Questionnaire validated for use with adolescent smokers.23

At each visit, subjects were queried about smoking, nicotine withdrawal, and use of any other cessation aids. Severity of 8 nicotine withdrawal symptoms (cigarette craving; depressed mood; irritability, frustration, or anger; anxiety; difficulty concentrating; restlessness; increased appetite or weight gain; and sleep disturbances) was assessed with a 5-point Likert scale in which 0 indicated not at all; 1, slight; 2, moderate; 3, quite a bit; and 4, extreme. Quantitative information on tobacco, alcohol, and other drug use was collected by means of a timeline follow-back method24,25 at each visit. Depression symptoms were assessed with the Children's Depression Inventory26 at baseline and 2 and 6 weeks.

OUTCOME MEASURES

The primary outcome measure was abstinence at 6 weeks as measured by 7-day point prevalence abstinence and 30-day prolonged abstinence. Seven-day point prevalence abstinence was defined as self-report of not smoking any part of a cigarette or tobacco product during the week before the visit. Thirty-day prolonged abstinence was defined as self-report of not smoking any part of a cigarette or other tobacco product in the 30 days preceding the visit. Self-reported abstinence was confirmed by exhaled CO level less than 10 ppm at each visit and urinary cotinine level less than or equal to 50 μg/L (to convert cotinine to nanomoles per liter, multiply by 5.675) (enzyme multiplied immunoassay technique) at the week 2 and 6 visits.

SAMPLE SIZE

Sample size was based on the ability to detect a 15% to 20% difference between treatment groups and placebo at 6 weeks of treatment, given a projected abstinence rate of 50% in the SR bupropion hydrochloride 300 mg/d group and 15% in the placebo group. Approximately 105 subjects were needed for each treatment group to have power of 0.90 and a 1-tailed significance level of .05.

STATISTICAL METHODS

Weekly point prevalence rates were calculated for each visit by means of subjects' self-reported diaries. Subjects were considered to be actively smoking during any week in which they recorded smoking 1 or more cigarettes. Efficacy comparisons are reported for all randomized subjects on an intention-to-treat basis. Abstinence rates were compared between placebo and treatment groups by χ2 statistics, specified a priori at a 1-tailed α = .05 significance level. Adverse event frequencies were compared between treatment and placebo by Fisher exact test (2-tailed). Treatment groups were compared, with adjustment for other potential confounders such as sex, ethnicity, and level of addiction, by logistic regression models.

Between April 2, 1999, and December 31, 2002, 312 adolescents were randomized (103 in the placebo group, 105 in the 150 mg/d group, and 104 in the 300 mg/d group). The last subject follow-up was completed in June 2003. Subject flow through the study is summarized in Figure 2. The most common reason for study exclusion (44%) was lack of motivation to quit smoking. Characteristics of the study sample are shown in Table 1. Subject race/ethnicity was self-described. Of note, approximately one-half of subjects had Fagerström nicotine dependence scores of 5 or higher. A score of 6 or higher generally indicates higher levels of dependence in adults. Scores associated with higher dependence levels in adolescents have not been well studied.

Place holder to copy figure label and caption
Figure 2.

Subject flow diagram. SR indicates sustained release. *Subject developed an exclusionary medical condition after randomization.

Graphic Jump Location
Table Graphic Jump LocationTable 1. Sample Demographics and Characteristics

Table 2 summarizes the self-reported weekly 7-day point prevalence abstinence rates. Table 3 presents the weekly 7-day point prevalence abstinence rates verified by breath CO and urine cotinine levels (week 6 only). Sustained-release bupropion hydrochloride, 150 mg/d, did not result in quit rates significantly higher than those with placebo at any time. Average CO-confirmed quit rates over the 6 weeks of medication treatment after the quit date were 11.5% in the placebo group, 15.3% in the 150 mg/d group, and 22.6% in the 300 mg/d group. Sustained-release bupropion hydrochloride, 300 mg/d, resulted in significantly higher quit rates than placebo at all time points during medication treatment, except at weeks 2 and 4.

Table Graphic Jump LocationTable 2. Seven-Day Point Prevalence Abstinence, Self-report
Table Graphic Jump LocationTable 3. Seven-Day Point Prevalence Abstinence, Confirmed by Carbon Monoxide or Cotininea

Six-week cotinine-verified abstinence demonstrated that only SR bupropion hydrochloride, 300 mg/d, resulted in higher quit rates than did placebo. After medication was discontinued following week 6 (end of treatment), observed differences in quit rates disappeared. There were no significant differences in either self-reported or confirmed 30-day prevalence abstinence rates. Logistic regression analyses assessing sex, ethnicity, and Fagerström score found no interactions with treatment group.

Safety was assessed on the basis of all self-reported adverse events throughout the study. Adverse events reported by at least 4% of the subjects are shown in Table 4. Only headache and cough occurred significantly more often in the active treatment groups than in the placebo group. Eight subjects discontinued bupropion treatment early because of the following adverse events: feeling depressed, irritable, or angry; sleep disturbance; headache; urticaria; anxiety; heart palpitations; suicide attempt; anticholinergic crisis related to recreational drug use; and pregnancy.

Table Graphic Jump LocationTable 4. Treatment-Emergent Adverse Eventsa

Two serious adverse events and 1 medically important event (defined by US Food and Drug Administration criteria for serious adverse event and medically important event) occurred during the study. A 16-year-old boy in the 150 mg/d group was hospitalized for anticholinergic crisis after deliberately ingesting Jimson weed (Datura innoxia) for recreational purposes. A 16-year-old girl in the 150 mg/d group was hospitalized for intentional overdose of study medication, other drugs, and alcohol in an apparent suicide attempt. Additional medical history obtained after the adverse event showed a previously undisclosed extensive history of depression and a probable eating disorder. This information, if disclosed at study screening, would have excluded the subject. The medically important event occurred in a 16-year-old girl in the placebo group who reported becoming pregnant shortly after her week 1 visit.

The present study has a number of strengths: dose-response study design, biochemical verification of abstinence, large sample size, and community-recruited subjects. The dose-response design was particularly important because key pivotal research on the efficacy of SR bupropion hydrochloride for adult cessation raised questions about a sufficient effect from 150 mg/d rather than 300 mg/d dosing.2729 We hypothesized that youths, on average, would weigh less than adults. Therefore, assessing equivalency of a lower dose—on the basis of either efficacy or tolerability—is essential. Our results indicate that only the 300 mg/d dosage was more efficacious for smoking cessation than placebo, and the effect appeared to be limited to the treatment phase. At baseline, the 300 mg/d group had significantly more adolescents who were older, had a history of longer previous quit attempts, and smoked more cigarettes. We interpreted these differences as being indicative of adolescents who are older, more established smokers, who are now trying to quit. We believe these differences would tend to bias against finding a treatment effect; thus, we are more confident in the significantly higher quit rates for the 300 mg/d group.

Biochemical verification of abstinence during the medication treatment phase of the study and at the 26-week follow-up visit resulted in quit rates that were consistent with, but an average of 14% to 23% lower than, self-reported outcomes. We are thus more confident in our outcomes as a result of verification.

The sample size was comparatively large for a youth smoking cessation medication study, thus resulting in greater power to detect meaningful differences, although we observed some possible trends (eg, the comparison between placebo and 150 mg) that will require even larger studies. However, a critical issue in conducting a larger study is the difficulty of recruiting youths into cessation studies.30

Community-based recruitment from real-world teen environments (schools, shopping malls, and teen clubs) was an essential strategy developed in response to inadequate subject accrual by conventional methods of clinical trial recruitment. Community-based recruitment ultimately became a significant study strength because it resulted in a more diverse study population (including minorities and youths not in school), thus increasing the study's external validity. However, we still struggled to achieve the required sample size. The increased diversity of the sample notwithstanding, generalizability is limited in that only 28.7% of subjects who completed initial screening were randomized. The most common reason for exclusion (44%) was lack of motivation to quit smoking. Future studies will need to consider recruitment challenges when planning timelines and recruitment resources.

Study limitations include modification of the study protocol (follow-up shortened from 52 weeks after the quit date to 26 weeks) to adjust for recruitment changes and a prolonged accrual period. Some characteristics of the more diverse community-recruited subjects could be associated with lower cessation rates. However, randomization should have equally distributed subject characteristics across treatment groups. Thus, we do not believe the main study outcomes were related to differences in recruitment.

The use of exhaled CO for biochemical confirmation of abstinence for all but the week 2 and week 6 (end-of-treatment) assessments is a limitation, due to CO's short half-life. Although the subjects were daily smokers (≥ 6 cigarettes per day), the cotinine-confirmed abstinence rates at the end of treatment were 50% to 65% lower than the CO-confirmed rates. The implication is that, even for adolescents who report daily smoking, the cotinine rather than CO level should be used to confirm abstinence in cessation trials.

Another possible study limitation is that study subjects received compensation for study participation, potentially influencing motivation for initial study enrollment and continued participation. Although this could influence overall motivation to quit, randomization would have resulted in a relatively equal distribution across the study conditions, so that motivation would not explain the differences between treatment groups.

The ability of study subjects to guess their treatment group, thus undermining the blind, is a potential limitation. However, only 10 subjects (9.6%) in the 300 mg group accurately guessed their treatment assignment. Across all treatment groups, there were no significant differences in the proportion of subjects who accurately guessed their treatment group.

This study demonstrates that SR bupropion hydrochloride at 300 mg/d plus brief behavioral counseling has short-term efficacy in helping adolescent smokers quit. However, abstinence rates at the end of treatment were less than those reported in bupropion cessation studies in adults. The 150 mg/d dosage did not result in increased quit rates but demonstrated a possible trend in the direction of increased cessation relative to placebo. Both dosages were generally well tolerated. These results are critically important because few effective treatment options are available for adolescent smokers who want to quit.

Despite the positive end-of-treatment outcome, subjects tended to relapse soon after discontinuing medication. This suggests a need to evaluate a longer dosing regimen in adolescent smokers, eg, 12 weeks, which would be consistent with current recommendations for treatment of adult smokers. In addition, further research is needed on interventions to prevent relapse, once medication treatment has ended. Nonetheless, this study provides hope for helping a generation of smokers quit before they become adults.

Correspondence: Myra L. Muramoto, MD, MPH, Department of Family and Community Medicine, The University of Arizona College of Medicine, PO Box 245052, Tucson, AZ 85704 (myram@email.arizona.edu).

Accepted for Publication: May 25, 2007.

Author Contributions: Drs Muramoto and Leischow contributed equally to this study. Drs Muramoto, Leischow, and Sherrill had full access to all of the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. Study concept and design: Muramoto, Leischow, and Strayer. Acquisition of data: Muramoto, Leischow, Matthews, and Strayer. Analysis and interpretation of data: Muramoto, Leischow, and Sherrill. Drafting of the manuscript: Muramoto, Leischow, Sherrill, and Matthews. Critical revision of the manuscript for important intellectual content: Muramoto, Leischow, and Strayer. Statistical analysis: Sherrill. Obtained funding: Muramoto, Leischow, Matthews, and Strayer. Administrative, technical, and material support: Muramoto, Leischow, Matthews, and Strayer. Study supervision: Muramoto, Leischow, and Strayer.

Financial Disclosures: Dr Muramoto has received research contracts from GlaxoSmithKline, Pfizer, and Sanofi-Aventis and is a speaker for Pfizer. Dr Leischow is a speaker and consultant for Pfizer, and at the time this study was conducted he was receiving research support from GlaxoSmithKline.

Funding/Support: This study was supported by National Cancer Institute grant RO1 CA77081 (financial support for all aspects of the study), The Robert Wood Johnson Foundation (financial support for all aspects of study), and GlaxoSmithKline (provided study medication and placebo, financial support for cotinine analyses, subject screening, data cleaning, and review of the draft manuscript; all data were maintained by the University of Arizona).

Additional Contributions: At the University of Arizona College of Medicine, Kimberly Elliot, BA, Coltron Islas, Michael Griffith, BS, and Steven Nez, BS, compiled CONSORT diagram data, and Terri Boitano, BA, edited the manuscript.

Centers for Disease Control, Cigarette use among high school students—United States, 1991-2005. MMWR Morb Mortal Wkly Rep 2006;55 (26) 724- 726
PubMed
US Department of Health and Human Services, Preventing Tobacco Use Among Young People: a Report of the Surgeon General.  Atlanta, GA US Dept of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health1994;
Chassin  LPresson  CCSherman  SJEdwards  DA The natural history of cigarette smoking. Health Psychol 1990;9 (6) 701- 716
PubMed
DiFranza  JRSavageau  JARigotti  NA  et al.  Development of symptoms of tobacco dependence in youths. Tob Control 2002;11 (3) 228- 235
PubMed
 Youth tobacco surveillance–United States, 2000. MMWR CDC Surveill Summ 2001;50 (4) 1- 84published correction appears in MMWR CDC Surveill Summ 2001;50 (46) 1036
PubMed
Sussman  SDent  CWSeverson  HHBurton  DFlay  BR Self-initiated quitting among adolescent smokers. Prev Med 1998;27 (5, pt 3) A19- A28
PubMed
Zhu  S-HSun  JBillings  SCChoi  WSMalarcher  AM Predictors of smoking cessation in U.S. adolescents. Am J Prev Med 1999;16 (3) 202- 207
PubMed
Engels  RCKnibbe  RAde Vries  HDrop  MJ Antecedents of smoking cessation among adolescents: who is motivated to change? Prev Med 1998;27 (3) 348- 357
PubMed
Sussman  S Effects of sixty-six adolescent tobacco use cessation trials and seventeen prospective studies of self-initiated quitting. Tob Induced Dis 2002;1 (1) 35- 81
Prokhorov  AVHudmon  KSde Moor  CAKelder  SHConroy  JLOrdway  N Nicotine dependence, withdrawal symptoms, and adolescents' readiness to quit smoking. Nicotine Tob Res 2001;3 (2) 151- 155
PubMed
Panday  SReddy  SPBergstrom  E A qualitative study on the determinants of smoking behaviour among adolescents in South Africa. Scand J Public Health 2003;31 (3) 204- 210
PubMed
Jacobsen  LKKrystal  JHMencl  WEWesterveld  MFrost  SJPugh  KR Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biol Psychiatry 2005;57 (1) 56- 66
PubMed
Moolchan  ETRobinson  MLErnst  M  et al.  Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction. Pediatrics 2005;115 (4) e407- e414
PubMed10.1542/peds.2004-1894
Stotts  RCRoberson  PKHanna  EYJones  SKSmith  CK A randomised clinical trial of nicotine patches for treatment of spit tobacco addiction among adolescents. Tob Control 2003;12(suppl 4)IV11- IV15
PubMed
Hanson  KAllen  SJensen  SHatsukami  D Treatment of adolescent smokers with the nicotine patch. Nicotine Tob Res 2003;5 (4) 515- 526
PubMed
Hurt  RDCroghan  GABeede  SDWolter  TDCroghan  ITPatten  CA Nicotine patch therapy in 101 adolescent smokers: efficacy, withdrawal symptom relief, and carbon monoxide and plasma cotinine levels. Arch Pediatr Adolesc Med 2000;154 (1) 31- 37
PubMed
Smith  TAHouse  RFCroghan  IT  et al.  Nicotine patch therapy in adolescent smokers. Pediatrics 1996;98 (4, pt 1) 659- 667
PubMed
Upadhyaya  HPBrady  KTWang  W Bupropion SR in adolescents with comorbid ADHD and nicotine dependence: a pilot study. J Am Acad Child Adolesc Psychiatry 2004;43 (2) 199- 205
PubMed
Killen  JDRobinson  TNAmmerman  S  et al.  Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers. J Consult Clin Psychol 2004;72 (4) 729- 735
PubMed
Lipkus  IMBarefoot  JCFeaganes  JWilliams  RBSiegler  IC A short MMPI scale to identify people likely to begin smoking. J Pers Assess 1994;62 (2) 213- 222
PubMed
Barrickman  LLPerry  PJAllen  AJ  et al.  Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1995;34 (5) 649- 657
PubMed
Conners  CKCasat  CDGualtieri  CT  et al.  Bupropion hydrochloride in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 1996;35 (10) 1314- 1321
PubMed
Prokhorov  AVPallonen  UEFava  JLDing  LNiaura  RS Measuring nicotine dependence among high-risk adolescent smokers. Addict Behav 1996;21 (1) 117- 127
PubMed
Sobell  LCSobell  MBLeo  GICancilla  A Reliability of a timeline method. Br J Addict 1988;83 (4) 393- 402
PubMed
Lewis-Esquerre  JMColby  SMTevyaw  TOEaton  CAKahler  CWMonti  PM Validation of the timeline follow-back in the assessment of adolescent smoking. Drug Alcohol Depend 2005;79 (1) 33- 43
PubMed
Kovacs  M Children's Depression Inventory Manual.  North Tonawanda, NY Multi-Health Systems1992;
Hurt  RDSachs  DPLGlover  ED  et al.  A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 1997;337 (17) 1195- 1202
PubMed
McAfee  TFrance  EK Sustained-release bupropion for smoking cessation [letter]. N Engl J Med 1998;338 (9) 619
PubMed
Swan  GEMcAfee  TCurry  SJ  et al.  Effectiveness of bupropion sustained release for smoking cessation in a health care setting: a randomized trial. Arch Intern Med 2003;163 (19) 2337- 2344
PubMed
Colby  SMMonti  PMO’Leary  TT  et al.  Brief motivational intervention for adolescent smokers in medical settings. Addict Behav 2005;30 (5) 865- 874
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Study visit flow diagram. *Clinic visit. †Telephone call.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Subject flow diagram. SR indicates sustained release. *Subject developed an exclusionary medical condition after randomization.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Sample Demographics and Characteristics
Table Graphic Jump LocationTable 2. Seven-Day Point Prevalence Abstinence, Self-report
Table Graphic Jump LocationTable 3. Seven-Day Point Prevalence Abstinence, Confirmed by Carbon Monoxide or Cotininea
Table Graphic Jump LocationTable 4. Treatment-Emergent Adverse Eventsa

References

Centers for Disease Control, Cigarette use among high school students—United States, 1991-2005. MMWR Morb Mortal Wkly Rep 2006;55 (26) 724- 726
PubMed
US Department of Health and Human Services, Preventing Tobacco Use Among Young People: a Report of the Surgeon General.  Atlanta, GA US Dept of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health1994;
Chassin  LPresson  CCSherman  SJEdwards  DA The natural history of cigarette smoking. Health Psychol 1990;9 (6) 701- 716
PubMed
DiFranza  JRSavageau  JARigotti  NA  et al.  Development of symptoms of tobacco dependence in youths. Tob Control 2002;11 (3) 228- 235
PubMed
 Youth tobacco surveillance–United States, 2000. MMWR CDC Surveill Summ 2001;50 (4) 1- 84published correction appears in MMWR CDC Surveill Summ 2001;50 (46) 1036
PubMed
Sussman  SDent  CWSeverson  HHBurton  DFlay  BR Self-initiated quitting among adolescent smokers. Prev Med 1998;27 (5, pt 3) A19- A28
PubMed
Zhu  S-HSun  JBillings  SCChoi  WSMalarcher  AM Predictors of smoking cessation in U.S. adolescents. Am J Prev Med 1999;16 (3) 202- 207
PubMed
Engels  RCKnibbe  RAde Vries  HDrop  MJ Antecedents of smoking cessation among adolescents: who is motivated to change? Prev Med 1998;27 (3) 348- 357
PubMed
Sussman  S Effects of sixty-six adolescent tobacco use cessation trials and seventeen prospective studies of self-initiated quitting. Tob Induced Dis 2002;1 (1) 35- 81
Prokhorov  AVHudmon  KSde Moor  CAKelder  SHConroy  JLOrdway  N Nicotine dependence, withdrawal symptoms, and adolescents' readiness to quit smoking. Nicotine Tob Res 2001;3 (2) 151- 155
PubMed
Panday  SReddy  SPBergstrom  E A qualitative study on the determinants of smoking behaviour among adolescents in South Africa. Scand J Public Health 2003;31 (3) 204- 210
PubMed
Jacobsen  LKKrystal  JHMencl  WEWesterveld  MFrost  SJPugh  KR Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biol Psychiatry 2005;57 (1) 56- 66
PubMed
Moolchan  ETRobinson  MLErnst  M  et al.  Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction. Pediatrics 2005;115 (4) e407- e414
PubMed10.1542/peds.2004-1894
Stotts  RCRoberson  PKHanna  EYJones  SKSmith  CK A randomised clinical trial of nicotine patches for treatment of spit tobacco addiction among adolescents. Tob Control 2003;12(suppl 4)IV11- IV15
PubMed
Hanson  KAllen  SJensen  SHatsukami  D Treatment of adolescent smokers with the nicotine patch. Nicotine Tob Res 2003;5 (4) 515- 526
PubMed
Hurt  RDCroghan  GABeede  SDWolter  TDCroghan  ITPatten  CA Nicotine patch therapy in 101 adolescent smokers: efficacy, withdrawal symptom relief, and carbon monoxide and plasma cotinine levels. Arch Pediatr Adolesc Med 2000;154 (1) 31- 37
PubMed
Smith  TAHouse  RFCroghan  IT  et al.  Nicotine patch therapy in adolescent smokers. Pediatrics 1996;98 (4, pt 1) 659- 667
PubMed
Upadhyaya  HPBrady  KTWang  W Bupropion SR in adolescents with comorbid ADHD and nicotine dependence: a pilot study. J Am Acad Child Adolesc Psychiatry 2004;43 (2) 199- 205
PubMed
Killen  JDRobinson  TNAmmerman  S  et al.  Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers. J Consult Clin Psychol 2004;72 (4) 729- 735
PubMed
Lipkus  IMBarefoot  JCFeaganes  JWilliams  RBSiegler  IC A short MMPI scale to identify people likely to begin smoking. J Pers Assess 1994;62 (2) 213- 222
PubMed
Barrickman  LLPerry  PJAllen  AJ  et al.  Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1995;34 (5) 649- 657
PubMed
Conners  CKCasat  CDGualtieri  CT  et al.  Bupropion hydrochloride in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 1996;35 (10) 1314- 1321
PubMed
Prokhorov  AVPallonen  UEFava  JLDing  LNiaura  RS Measuring nicotine dependence among high-risk adolescent smokers. Addict Behav 1996;21 (1) 117- 127
PubMed
Sobell  LCSobell  MBLeo  GICancilla  A Reliability of a timeline method. Br J Addict 1988;83 (4) 393- 402
PubMed
Lewis-Esquerre  JMColby  SMTevyaw  TOEaton  CAKahler  CWMonti  PM Validation of the timeline follow-back in the assessment of adolescent smoking. Drug Alcohol Depend 2005;79 (1) 33- 43
PubMed
Kovacs  M Children's Depression Inventory Manual.  North Tonawanda, NY Multi-Health Systems1992;
Hurt  RDSachs  DPLGlover  ED  et al.  A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 1997;337 (17) 1195- 1202
PubMed
McAfee  TFrance  EK Sustained-release bupropion for smoking cessation [letter]. N Engl J Med 1998;338 (9) 619
PubMed
Swan  GEMcAfee  TCurry  SJ  et al.  Effectiveness of bupropion sustained release for smoking cessation in a health care setting: a randomized trial. Arch Intern Med 2003;163 (19) 2337- 2344
PubMed
Colby  SMMonti  PMO’Leary  TT  et al.  Brief motivational intervention for adolescent smokers in medical settings. Addict Behav 2005;30 (5) 865- 874
PubMed

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 23

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles