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Article |

Improving Attention-Deficit/Hyperactivity Disorder Treatment Outcomes Through Use of a Collaborative Consultation Treatment Service by Community-Based Pediatricians:  A Cluster Randomized Trial FREE

Jeffery N. Epstein; David Rabiner, PhD; Diane E. Johnson, PhD; David P. FitzGerald, PhD; Allan Chrisman, PhD; Alaattin Erkanli, MD; Kevin K. Sullivan, PhD; John S. March, BS; Peter Margolis, MD; Edward C. Norton, MD, PhD; C. Keith Conners, PhD
[+] Author Affiliations

Author Affiliations: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (Drs Epstein and Margolis); Department of Public Policy, Duke University, Durham, North Carolina (Dr Rabiner); Departments of Psychiatry (Drs Johnson, FitzGerald, Chrisman, March, and Conners, and Mr Sullivan) and Biostatistics and Bioinformatics (Dr Erkanli), Duke University Medical Center, Durham, North Carolina; and Department of Health Policy and Administration, University of North Carolina, Chapel Hill (Dr Norton).


Arch Pediatr Adolesc Med. 2007;161(9):835-840. doi:10.1001/archpedi.161.9.835.
Text Size: A A A
Published online

Objective  To test whether adoption of a collaborative consultative service model results in improved patient outcomes.

Design  Twelve pediatric practices were randomly assigned to receive access to collaborative consultative services or to a control group.

Setting  Community-based pediatric offices.

Participants  Fifty-two pediatricians and their 377 patients with attention-deficit/hyperactivity disorder (ADHD).

Intervention  A collaborative consultative service promoting the use of titration trials and periodic monitoring during medication maintenance.

Main Outcome Measure  Physician practice behaviors and child ADHD symptomatology.

Results  Using self-report of pediatricians, the collaborative consultative service increased the use of evidence-based practices by pediatricians, but no difference in children's ADHD symptomatology was observed between the groups. However, many pediatricians did not fully use the collaborative consultative services. Those children who actually received collaborative consultative services showed significant behavioral improvement compared with children not receiving these services.

Conclusions  When actually implemented by pediatricians, the collaborative consultative service appears to be an effective method for facilitating evidence-based treatment procedures for ADHD and use of these procedures appear to improve children's outcomes. Barriers to implementation of collaborative consultative service in pediatric practice need to be further understood.

Figures in this Article

Primary care physicians are the main providers of treatment to children with attention-deficit/hyperactivity disorder (ADHD),1,2 and most of these physicians prescribe psychopharmacological treatments for their patients with ADHD.3 Although the efficacy of these medications is well documented,4 results from the Multimodal Treatment Study of ADHD in children suggests that intensive medication management that includes careful titration and regular monitoring can improve child outcomes compared with typical medication-prescribing practices.5

Unfortunately, practices similar to those used in the Multimodal Treatment Study of ADHD can be challenging to implement in community practice settings6 for a variety of reasons, which include inadequate reimbursement and lack of time and resources.7 A collaborative consultation service,8 which promotes the collaboration between community-based physicians (eg, pediatricians) and mental health professionals (eg, psychiatrists), may be able to address some of these issues. Collaborative consultation service models use experts in mental health to score and interpret behavioral ratings collected by the pediatrician during assessment, titration of medication, or medication maintenance, and a report on the behavioral findings is provided to the pediatrician to help guide diagnostic and treatment decisions. Such collaborative consultation service models that focus on assessing ADHD have been described elsewhere9,10 and are reported to be successful at improving adherence to practice behaviors recommended by the American Academy of Pediatrics.10

Similar collaborative consultation service models have been used to promote the use of titration trials and periodic monitoring during medication maintenance.1114 An important limitation of this work, however, is that impact of such a service on children's treatment outcomes has not been evaluated. Our study was intended to address this gap in the literature by examining whether a collaborative consultation model to promote the use of titration trials and systematic monitoring would increase the use of these practices across multiple pediatric groups and whether this would yield better management of core ADHD symptoms in children with the disorder.

PARTICIPANTS
Pediatricians

Twelve pediatric practice groups (ie, > 1 health care provider) that had no on-site psychologist or psychiatrist and that used a computerized billing system were identified using a statewide physician directory. The recruitment goals were to get consent from and enroll the maximum number of pediatricians at the minimum number of practices and to select typical office settings. Across the 12 practices, a total of 52 pediatricians (27 men and 25 women) or associated health care professionals (eg, physician assistants) participated.

Children

After consenting to participate in the study, physicians consented for and enrolled stimulant-naïve children in first through fifth grades who presented with an ADHD-related problem (377 children). A randomly selected sample of 146 children, all of whom met Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) criteria for ADHD, as determined by parent and teacher versions of the Conners Rating Scale, was recruited for follow-up to assess child outcomes. An attempt was made to select equal numbers of patients across pediatricians by randomly selecting a single child from each pediatrician every 2 months. Hence, the maximum number of children included in the study seen by a single pediatrician was 6, but could be fewer if a pediatrician did not see a child who met inclusion criteria during a 2-month period. Ninety-three of these children were boys. Most participants were white (white, n = 116 [79.5%]; African American, n = 24; American Indian, n = 1; Hispanic, n = 1; multiracial, n = 3; not reported, n = 1). Mean age was 7.8 years (SD, 1.5 years).

DESIGN

The 12 practices were randomly assigned to receive the collaborative consultation service or not (control group). Practices representing similar geographic location and size were randomized in blocks of 2. In practices assigned to the collaborative consultation service group, pediatricians were assisted in using titration trials to determine optimal dosages for children and using rating scales to monitor medication efficacy and side effects during medication maintenance. They were encouraged to use these services with all of their stimulant-naïve patients with ADHD in grades first through fifth for whom they opted to prescribe medication. Control group practices did not have access to consultative model services. The flowchart for this cluster randomized trial is shown in Figure 1. The study was approved by the Duke University Medical Center institutional review board.

Place holder to copy figure label and caption
Figure 1.

Flowchart for the cluster randomized trial. ADHD indicates attention-deficit/hyperactivity disorder; HCP, health care professional.

Graphic Jump Location
COLLABORATIVE CONSULTATION SERVICE

Physicians were taught to prescribe 4 different weekly dosages of stimulant medication during a titration trial. For purposes of this study, the following doses were packaged together: placebo and 18 mg, 36 mg, and 54 mg of methylphenidate hydrochloride. The order of weekly dosages was blinded but standardized across all patients (week 1, 18 mg; week 2, placebo; week 3, 36 mg; week 4, 54 mg). These packaged medications were made available through local pharmacies. At the end of each week, parents and teachers completed weekly behavioral (Conners Global Index)15 and side effect16 rating scales. These were returned to the Duke University Medical Center ADHD Clinic, where data were analyzed by Duke psychiatrists to determine a best starting dosage of medication. A report describing the titration results was faxed back to pediatricians. Subsequently, parents and teachers completed monthly behavioral and side effect rating scales. These were sent to the Duke University Medical Center ADHD Clinic, where reports were prepared to alert pediatricians to any behavioral deteriorations or appearance of side effects.

MEASURES

Study measures were incorporated, which measured both pediatricians' behaviors and child outcomes. Practice behaviors, knowledge related to the use of titration trials, and systematic monitoring of medication effectiveness were assessed using surveys that were administered preintervention and postintervention. Specifically, pediatricians were asked about how frequently they used titration trials and systematic monitoring of medication treatment over time and the obstacles they experienced in using these practices (eg, lack of time).

To assess children's core ADHD symptoms over the course of the study, researchers used the Conners Parent Rating Scale and the Conners Teacher Rating Scale15 at 0, 3, and 12 months after study entry. The DSM-IV symptoms scores from the Conners Parent Rating Scale and the Conners Teacher Rating Scale served as the primary child outcome measures. Parents and teachers were compensated for completing research forms. No compensation was provided for completion of clinically related questionnaires and forms.

ANALYSES

In this randomized design, pediatricians were nested within practice and children were nested within pediatrician and practice. Hierarchical linear models were used to account for these nested effects. Pediatric office and pediatrician were introduced as effects in the models. Across all analyses, however, the variance components associated with these nested random effects were negligible. Hence, we dropped practice and pediatrician from the analyses.

Each pediatrician had 2 repeated observations on each variable (preintervention and postintervention), and children had 3 repeated observations on each variable (at baseline and 3 and 12 months). Multivariate normal regression models were conducted using time (preintervention and postintervention) and group status (collaborative consultation service or control group) as independent variables. For analyses of child effects, an additional variable for the rater was included so that parent and teacher ratings could be included in a single analysis. Significant group × time interaction terms would indicate any intervention effects.

For children randomly selected for follow-up, data collection was to occur at baseline and 3 and 12 months. Of 146 participants selected for follow-up, 45 had data from all 3 data points. The remaining 101 participants had at least 1 missing data point. These missing data points reflect the difficulty of obtaining completed rating scales from a number of parents and teachers despite multiple requests via telephone and mail. Data were assumed to be missing at random. Indeed, a comparison of children with missing data on DSM-IV–defined ADHD symptomatology at baseline with those who had complete data demonstrated no group differences (F1,144 = 1.10, P = .30). This supported the missing-at-random assumption and hence all observations were kept in the analyses.

PEDIATRICIAN PRACTICE BEHAVIOR

Randomizing the 12 practice groups resulted in 25 pediatricians in the collaborative consultation service group and 27 in the control group. The 2 groups did not differ in sex composition (P = .25) or number of years since their residency (collaborative consultation service group mean, 9.76 years [SD, 10.13]; control group mean, 9.07 years [SD, 7.25]; P = .78). In addition, the percentage of physicians in each group (84% of the collaborative consultation service group; 93% of the control group) did not differ (P = .31). Five pediatricians in the control group (24%) and 9 pediatricians in the intervention group (36%) did not enroll any children in the study. Responses from these pediatricians on the preintervention and postintervention questionnaire were not included in the analyses reported subsequently.

There were greater preintervention to postintervention improvements in the use of titration trials among the collaborative consultation service pediatricians compared with control-group pediatricians (interaction, β = − .283; SE, 0.09; P < .01) (Figure 2). Specifically, titration trials in the intervention group increased from 9% to 68% compared with no increase in the control group (P < .001). Although both groups increased their use of monthly rating scales to monitor medication during maintenance (40%- 64% for the collaborative consultation service group and 29%-50% for the control group; time effect, β = .200; SE, 07; P < .01), monitoring did not increase more among pediatricians in the collaborative consultation service group, and more than one-third were still not conducting regular, systematic monitoring of medication treatment.

Place holder to copy figure label and caption
Figure 2.

Percentage of children with whom intervention and control pediatricians used titration trials and periodically monitored the effectiveness of prescribed medication based on pediatricians' self-reports.

Graphic Jump Location

Pediatricians with access to the collaborative consultation service reported decreases across all obstacles. The greatest decreases were on items concerning lack of time to conduct a titration trial (odds ratio, 6.3; SE, 3.5), lack of knowledge about how to conduct a titration trial (odds ratio, 5.5; SE, 3.1), and how to interpret monthly rating scale scores during medication maintenance (odds ratio, 3.7; SE, 2.1) (Table).

Table Graphic Jump LocationTable. Pediatricians Who Cited Obstacles Preventing Implementation of Evidence-Based ADHD Treatment
CHILD OUTCOMES

Collaborative consultation service pediatricians enrolled 162 patients (mean, 8.5 patients per physician [SD, 5.2]) while control-group practices enrolled 215 patients (mean, 8.2 patients per physician [SD, 4.6]). Of the 146 children who were randomly selected for follow-up, 59 were patients of collaborative consultation service pediatricians and 87 were patients of control-group pediatricians. Parents, in comparison with teachers, rated the children as having less ADHD symptomatology overall (F1,144 = − 31.74, P < .001). Although ADHD symptomatology decreased over time (F2,144 = 143.65, P < .001), child outcomes did not differ by group (F1,144 = 0.05, P = .83) and the interaction testing for the intervention effect (ie, group × time) was nonsignificant (F2,144 = 0.44, P = .65).

However, only 29 of the 59 randomly selected follow-up patients of collaborative consultation service pediatricians received a titration trial and even fewer participated in the monthly medication monitoring (n = 13). An additional set of analyses were performed to detect whether patients who were minimally exposed to the intervention, defined by experiencing a titration trial, had better outcomes than nonexposed children. In this analysis, groups of collaborative consultation service compliers (those receiving a titration trial [n = 29]) and collaborative consultation service noncompliers (those not receiving a titration trial [n = 30]) were compared with each other and to children treated by control-group physicians. A preliminary analysis indicated that these groups were comparable at baseline on both parent (F1,57 = 1.80, P > .05) and teacher ADHD ratings (F1,40 = 0.22, P > .05).

After treatment began, the 3 groups were rated differently overall (F2,143 = 3.45, P < .05) and the intervention effect (group × time) was significant (F4,124 = 3.80, P < .01), with children in the collaborative consultation service–complier group having better treatment trajectories than children in the collaborative consultation service–noncomplier and control groups (Figure 3). Children in the collaborative consultation service–complier group demonstrated a 27% reduction in DSM-IV symptomatology compared with an 18% reduction in the control group and a 13% reduction in the noncompliers. The reduction in the compliers group was significantly greater than that seen in the control group (t114 = − 2.72, P = .008, effect size = 0.25) and in the noncomplier group (t57 = − 3.568, P <.001, effect size = 0.47).

Place holder to copy figure label and caption
Figure 3.

Parent (A) and teacher (B) ratings of attention-deficit/hyperactivity disorder symptomatology for children seen by collaborative consultation service pediatricians who used these services (compliers), children seeing collaborative consultation service pediatricians who did not use these services (noncompliers), and children seen by control-group pediatricians (controls).

Graphic Jump Location
EXPLORATORY ANALYSIS OF OUTCOME DIFFERENCE BETWEEN COMPLIERS, NONCOMPLIERS, AND CONTROLS

We were particularly interested in whether group differences were related to differences in the medication treatment, specifically whether children who received titration trials were more likely to be receiving medication at long-term follow-up and whether there is a difference in the dosage or type of medication that they received. Not surprisingly, children whose parents refused the titration trial were less likely to be receiving medication at 12 months (53%) than compliers (91% [n = 40]; χ21 = 7.67, P < .01) or controls (87% [n = 79]; χ21 = 8.36, P < .01).

We next examined whether there were differences in the dosage of medication that compliers and control participants were receiving. Because methylphenidate was the medication used in titration, it is not surprising that a larger percentage of compliers than control participants were receiving methylphenidate at 12 months (73% vs 41%). However, it is noteworthy that the mean daily dosage of methylphenidate hydrochloride was significantly higher for compliers than controls (33 mg vs 25.8 mg [F1,35 = 5.60, P < .05]) and that control participants were more likely than compliers to be on the lowest possible daily dosage of 18 mg (12 of 22 controls [55%] vs only 3 of 15 compliers [20%]; χ21 = 4.42, P < .05).

Overall, the consultation model increased the use of some evidence-based ADHD treatment strategies among community pediatricians. Furthermore, although the intent-to-treat analyses were not significant, there was evidence that children receiving a medication trial had lower rates of core ADHD symptoms at 12 months, perhaps because they were more likely to be maintained on an appropriate therapeutic dosage. These findings echo results from the Multimodal Treatment Study of ADHD, where children receiving medication in community settings received lower dosages than children whose treatment began with a titration trial to determine the optimal starting maintenance dosage.5 To our knowledge, this is the first demonstration that the use of titration trial procedures by community pediatricians, albeit with support provided by university-based consultation, is associated with better management of ADHD symptoms.

Despite these encouraging findings, many pediatricians either failed to use the collaborative consultation services entirely or did not take full advantage of collaborative consultation services. Hence, our results also highlight the difficulties of changing practice behaviors and are consistent with a prior report in which low rates of use of consultative ADHD treatment services were found.11 In our study, the collaborative consultation service that was most inconsistently used was the periodic treatment monitoring during medication maintenance. This is especially troubling given that systematic treatment monitoring is an important recommendation in the American Academy of Pediatrics' treatment guidelines17 and may be especially important for promoting the long-term success of children with ADHD.18 It is clear that additional strategies are necessary to promote the use of periodic monitoring of medication efficacy and side effects by pediatricians. Additional research is necessary to determine what the barriers were that impeded implementation. Perhaps adoption of quality-improvement methodology, whereby practices monitor their own compliance with prescribed guidelines, would have been useful.19 If such data were regularly acquired, physicians could be provided with periodic feedback on their own performance in comparison with other pediatricians. Such quality-improvement methods have been shown to change physicians' practice behaviors with other medical conditions.20

There are several important limitations to our study, which should be noted. First, the collaborative consultation service focused entirely on pharmacological treatment, whereas studies such as the Multimodal Treatment Study of ADHD have suggested that a multimodal treatment strategy may result in better outcomes among children with diagnosed ADHD.21 Other studies that promote evidence-based psychosocial treatment for children with ADHD in pediatric settings are thus necessary. Another limitation is that pediatrician practice behavior was measured through self-report, which can be inaccurate owing to response bias. However, based on medical record review, we found that pediatricians' self-report about use of titration trials was largely consistent with what was documented for the randomly selected sample of follow-up children during that year (68% vs 59%). Thus, it does not appear that collaborative consultation service pediatricians were grossly inflating their use of this practice.

Further, in evaluating child outcomes, total ADHD symptomatology as measured by parent and teacher report was selected a priori as the primary outcome measure. We focused on core ADHD symptoms, because Multimodal Treatment Study of ADHD results indicated that a pharmacological treatment strategy produced the largest effect on this outcome. However, we recognize that a more comprehensive test of medication effects would have included measurement of other child outcomes (eg, functional impairment). This broader assessment of outcomes was not feasible in our study, but should be included in future work. Another important limitation is that, because practices volunteered for the study, it is likely that participants were those who believed they could benefit from the intervention and were open to practice change. Not all pediatricians or pediatric practices are necessarily open to practice changes, however. Had a random sample of pediatric practices been selected to participate, regardless of their interest in the project, compliance would likely have been attenuated.

We experienced several methodological limitations inherent to evaluating a community-based model such as this. First, randomization was complicated because it needed to occur at the practice level as opposed to the patient level; this created a nested design, which poses several statistical challenges. Second, the researchers had no clinical contact with the patients on whom outcome data were being collected, and all research-related data was collected through the mail or over the telephone. A consequence of no researcher-patient contact was inflated rates of drop-out and missing data compared with clinic-based studies. We also do not know how many children who may have been appropriate for the study were not enrolled. We used statistical strategies, where possible, to correct for some of these methodological deficiencies in our community-based design. However, these strategies may be limited in fully correcting these methodological challenges, which, in addition to accompanying limitations, are inherent to community-based research and must be weighed against the value of conducting this type of research.

Finally, we acknowledge that the lack of statistically significant between-group differences in the initial intent to treat may have been caused by low rates of collaborative consultation services use by the physicians. Had more of the children in the intervention group experienced titration trials and monitoring of medication maintenance, the power of the overall analyses to detect treatment differences would have likely improved and the primary analyses might have reached statistical thresholds for significance.

Although promoting this collaborative consultation service model to all pediatricians may prove difficult, we believe that there is a compelling need for this type of service. Many pediatricians in this study expressed the need for expert assistance and consultation when treating children with ADHD. If such a collaborative consultation service intervention were to be disseminated on a wider basis, consideration would need to be given to alternative modes of data collection and report delivery. Alternative modalities for delivering the described services need exploration. Such modalities may include the Internet or personal handheld devices.22

In summary, the consultative model used here and described by others11 provides an example of how the divide between science and practice can be bridged in the treatment of ADHD. Pediatricians have to address a multitude of physical and mental disorders during the course of daily practice, and applying evidence-based methods to all these disorders, even when prescribed by the American Academy of Pediatrics, can be quite difficult.23 This model helped pediatricians overcome many of the common obstacles to conducting careful medication trials24 and showed promise in helping pediatricians' practice behaviors more closely approximate the evidence-based techniques recommended by the American Academy of Pediatrics. Furthermore, use of these evidence-based practices appeared to promote greater reduction in core ADHD symptoms in the subgroup of children who were exposed to the intended treatment. In subsequent work, it will be important to identify methods to further reduce physicians' obstacles to more fully using the consultation services that were provided and to evaluate the impact of these services on a wider range of child outcomes.

Correspondence: Jeff N. Epstein, PhD, Cincinnati Children's Hospital Medical Center, 2800 Winslow St, Room 2216, Cincinnati, OH 45206 (jeff.epstein@cchmc.org).

Accepted for Publication: March 30, 2007.

Author Contributions: Dr Epstein had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Epstein, Rabiner, Johnson, March, and Margolis. Acquisition of data: Epstein, Johnson, and FitzGerald. Analysis and interpretation of data: Epstein, Chrisman, Erkanli, Sullivan, March, Margolis, Norton, and Conners. Drafting of the manuscript: Epstein, Johnson, Chrisman, Erkanli, Sullivan, and Norton. Critical revision of the manuscript for important intellectual content: Epstein, FitzGerald, Erkanli, March, Margolis, and Conners. Statistical analysis: Erkanli and Norton. Obtained funding: Epstein, Rabiner, Johnson, and March. Administrative, technical, and material support: Epstein, Johnson, FitzGerald, Chrisman, Sullivan, March, Margolis, and Conners. Study supervision: Epstein and FitzGerald.

Financial Disclosure: McNeil Consumer and Specialty Pharmaceuticals provided the packaged medication for this research study.

Funding/Support: This research was supported by grant MH61367 from the National Institute of Health (Dr Epstein).

Additional Contributions: William Brinkman, MD, gave helpful comments and feedback on the manuscript.

Bussing  RZima  BTBelin  TR Differential access to care for children with ADHD in special education programs. Psychiatr Serv 1998;49 (9) 1226- 1229
PubMed
Rappley  MDGardiner  JTetton  JHouang  R The use of methylphenidate in Michigan. Arch Pediatr Adolesc Med 1995;149 (6) 675- 679
PubMed Link to Article
Hoagwood  KJensen  PSFeil  MVitiello  BBhatara  V Medication management of stimulants in pediatric practice settings: a national perspective. J Dev Behav Pediatr 2000;21 (5) 322- 331
PubMed Link to Article
Swanson  JMMcBurnett  KWigal  T  et al.  Effect of stimulant medication on children with attention deficit disorder: a review of reviews. Except Child 1993;60154- 162
Jensen  PSHinshaw  SSwanson  J  et al.  Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers. J Dev Behav Pediatr 2001;22 (1) 60- 73
PubMed Link to Article
Leslie  LK The role of primary care physicians in attention-deficit/hyperactivity disorder. Pediatr Ann 2002;31 (8) 475- 484
PubMed Link to Article
Cabana  MDRand  CPowe  N  et al.  Why don't physicians follow clinical practice guidelines? a framework for improvement. JAMA 1999;282 (15) 1458- 1465
PubMed Link to Article
Pace  TMChaney  JMMullins  LLOlson  RA Psychological consultation with primary care physicians: obstacles and opportunities in the medical setting. Prof Psychol Res Pr 1995;26123- 131
Link to Article
Olson  BGRosenbaum  PFDosa  NPRoizen  NJ Improving guideline adherence for the diagnosis of ADHD in an ambulatory pediatric setting. Ambul Pediatr 2005;5 (3) 138- 142
PubMed Link to Article
Leslie  LKWeckerly  JPlemmons  DLandsverk  JEastman  S Implementing the American Academy of Pediatrics attention-deficit/hyperactivity disorder diagnostic guidelines in primary care settings. Pediatrics 2004;114 (1) 129- 140
PubMed Link to Article
Nikles  CJMitchell  GKDel Mar  CBClavarino  AMcNairn  N An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics 2006;117 (6) 2040- 2046
PubMed Link to Article
Fine  SJewesson  B Active drug placebo trial of methylphenidate: a clinical service for children with an attention deficit disorder. Can J Psychiatry 1989;34 (5) 447- 449
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Guyatt  GHKeller  JLJaeschke  RRosenbloom  DAdachi  JDNewhouse  MT The n-of-1 randomized controlled trial: clinical usefulness, our three-year experience. Ann Intern Med 1990;112 (4) 293- 299
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Pelham  WE  Jr Pharmacotherapy of children with attention-deficit hyperactivity disorder. School Psych Rev 1993;22 (2) 199- 227
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American Academy of Child and Adolescent Psychiatry, Practice parameters for the assessment and treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1991;30 (3) I- III
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Vreeman  RCMadsen  KAVreeman  DJCarroll  AEDowns  SM Compliance with guidelines for ADHD: a pilot study of an evaluation tool. J Pediatr 2006;149 (4) 568- 571
PubMed Link to Article
Margolis  PALannon  CMStuart  JMFried  BJKeyes-Elstein  LMoore  DE Practice based education to improve delivery systems for prevention in primary care: randomised trial. BMJ 2004;328 (7436) 388
PubMed Link to Article
Conners  CKEpstein  JNMarch  JS  et al.  Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry 2001;40 (2) 159- 167
PubMed Link to Article
Sargent  JD Web-based assistance for physicians caring for children with ADHD. Eff Clin Pract 2001;4 (3) 127- 135
PubMed
Pearson  MG How can the implementation of guidelines be improved? Chest 2000;117 (2) (suppl)38S- 41S
PubMed Link to Article
Williams  JKlinepeter  KPalmes  GPulley  AFoy  JM Diagnosis and treatment of behavioral health disorders in pediatric practice. Pediatrics 2004;114 (3) 601- 606
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Flowchart for the cluster randomized trial. ADHD indicates attention-deficit/hyperactivity disorder; HCP, health care professional.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Percentage of children with whom intervention and control pediatricians used titration trials and periodically monitored the effectiveness of prescribed medication based on pediatricians' self-reports.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Parent (A) and teacher (B) ratings of attention-deficit/hyperactivity disorder symptomatology for children seen by collaborative consultation service pediatricians who used these services (compliers), children seeing collaborative consultation service pediatricians who did not use these services (noncompliers), and children seen by control-group pediatricians (controls).

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Pediatricians Who Cited Obstacles Preventing Implementation of Evidence-Based ADHD Treatment

References

Bussing  RZima  BTBelin  TR Differential access to care for children with ADHD in special education programs. Psychiatr Serv 1998;49 (9) 1226- 1229
PubMed
Rappley  MDGardiner  JTetton  JHouang  R The use of methylphenidate in Michigan. Arch Pediatr Adolesc Med 1995;149 (6) 675- 679
PubMed Link to Article
Hoagwood  KJensen  PSFeil  MVitiello  BBhatara  V Medication management of stimulants in pediatric practice settings: a national perspective. J Dev Behav Pediatr 2000;21 (5) 322- 331
PubMed Link to Article
Swanson  JMMcBurnett  KWigal  T  et al.  Effect of stimulant medication on children with attention deficit disorder: a review of reviews. Except Child 1993;60154- 162
Jensen  PSHinshaw  SSwanson  J  et al.  Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers. J Dev Behav Pediatr 2001;22 (1) 60- 73
PubMed Link to Article
Leslie  LK The role of primary care physicians in attention-deficit/hyperactivity disorder. Pediatr Ann 2002;31 (8) 475- 484
PubMed Link to Article
Cabana  MDRand  CPowe  N  et al.  Why don't physicians follow clinical practice guidelines? a framework for improvement. JAMA 1999;282 (15) 1458- 1465
PubMed Link to Article
Pace  TMChaney  JMMullins  LLOlson  RA Psychological consultation with primary care physicians: obstacles and opportunities in the medical setting. Prof Psychol Res Pr 1995;26123- 131
Link to Article
Olson  BGRosenbaum  PFDosa  NPRoizen  NJ Improving guideline adherence for the diagnosis of ADHD in an ambulatory pediatric setting. Ambul Pediatr 2005;5 (3) 138- 142
PubMed Link to Article
Leslie  LKWeckerly  JPlemmons  DLandsverk  JEastman  S Implementing the American Academy of Pediatrics attention-deficit/hyperactivity disorder diagnostic guidelines in primary care settings. Pediatrics 2004;114 (1) 129- 140
PubMed Link to Article
Nikles  CJMitchell  GKDel Mar  CBClavarino  AMcNairn  N An n-of-1 trial service in clinical practice: testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics 2006;117 (6) 2040- 2046
PubMed Link to Article
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