We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
The Pediatric Forum |

Against Newborn Screening for Type 1 Diabetes—Reply

Olli Simell, MD, PhD
Arch Pediatr Adolesc Med. 2007;161(6):616-618. doi:10.1001/archpedi.161.6.617.
Text Size: A A A
Published online


In reply

We wish to thank Dr Ross for her interest in our study. We absolutely agree that newborn screening for genetic risk for type 1 diabetes mellitus should not be offered as a part of general screening programs before safe and effective preventive measures have been developed. However, in carefully constructed research framework with appropriate counseling facilities and close follow-up schedules, the situation is very different.

The existing data indicate that parental anxiety is not significantly elevated after receiving the risk information and seems to further dissipate over time 14; however, there is considerable variation depending on the ethnic background and education level of the parents, for example.1 In the extremely ethnically homogeneous and uniformly well-educated Finnish population, which is the target in the Type 1 Diabetes Prediction and Prevention study, these problems are probably smaller than in many other countries. However, the worry about at least transient psychological and emotional untoward effects is real and well recognized by researchers. Unrelated negative life experiences and stress will play a role in the psychological impact of the risk information, and it is extremely important to learn to recognize families who need special attention and to develop tools for supportive measures. These aspects are actively monitored and investigated in the Type 1 Diabetes Prediction and Prevention Project as well as in other type 1 diabetes mellitus natural history and prevention study protocols that share the same approach. Every effort is taken to find ways to minimize the burden on the family.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





June 1, 2007
Lainie Friedman Ross, MD, PhD
Arch Pediatr Adolesc Med. 2007;161(6):616-618. doi:10.1001/archpedi.161.6.616-c.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Diabetes, Foot Ulcer

Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Clarifying Your Question