Early identification of autism offers the possibility of early intervention, which holds promise for improving the outcomes of children with autism. This study investigated the tendency to respond to one's name in infants at risk of autism spectrum disorder compared with those with no known increased risk. At 6 months of age, 80% of infants not at risk, but only 64% of at-risk infants, responded on the first or second call of their name. At 12 months, all control infants, but 86% of at-risk infants, responded to 1 or 2 calls of their name. Only 50% of the at-risk infants responded appropriately at both 6 and 12 months of age. The sensitivity of response to the calling of one’s name at 2 months for any developmental delay at 24 months was 39%, with a specificity of 94%. Children who fail to respond to their name at 12 months warrant further developmental evaluation.