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August 1997, Vol 151, No. 8 >
Article | August 1997

Radiological Case of the Month FREE

Mitchell H. DeJonge, MD
Arch Pediatr Adolesc Med. 1997;151(8):845-846. doi:10.1001/archpedi.1997.02170450095016.
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A NEONATE weighing 739 g was delivered by cesarean section as the second of triplets at 253/7 weeks of gestation. The neonate was empirically treated with ampicillin sodium and gentamicin sulfate for 7 days, with the discontinuance of medication followed by clinical deterioration, which led to the institution of 2 separate 3-day treatment courses of vancomycin and cefotaxime sodium. At 11 days of age, dexamethasone treatment was started for severe lung disease. Blood, urine, and cerebrospinal fluid cultures obtained at 4 weeks grew Candida albicans and antifungal treatment with amphotericin B and oral flucytosine was started. Echocardiogram, renal ultrasonogram, cranial ultrasonogram, and eye evaluation results were normal at this time. One week after the antifungal treatment was started, a cranial ultrasonogram study showed left periventricular hyperechoic regions and mild ventricular dilation. The cerebrospinal fluid from lumbar puncture was negative for C albicans but showed a protein level of 2.38 g/L.

REFERENCES

1 +
Baley JE, Kliegman RM, Fanaroff M.  Disseminated fungal infections in very lowbirth-weight infants: clinical manifestations and epidemiology . Pediatrics . 1984;; 73:144-152.
2 +
Johnson DE, Thompson TR, Green TP, Ferrieri P.  Systemic candidiasis in very low-birth-weight infants (<1500 grams) . Pediatrics . 1984;;73:138-143.
3 +
Baley JE, Annable WL, Kliegman RM.  Candida endophthalmitis in the premature infant . J Pediatr . 1981;;98:458-461.
4 +
Faix RG.  Systemic Candida infections in infants in intensive care nurseries: high incidence of central nervous system involvement . J Pediatr . 1984;;105:616-622.
5 +
Thron A, Wietholter H.  Cerebral candidiasis: CT studies in a case of brain abscess and granuloma due to Candida albicans . Neuroradiology . 1982;;23:223-225.
6 +
Ikeda K, Yamashita J, Fujisawa H, Fujita S.  Cerebral granuloma and meningitis caused by Candida albicans: useful monitoring of mannan antigen in cerebrospinal fluid . Neurosurgery . 1990;;26:860-863.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Baley JE, Kliegman RM, Fanaroff M.  Disseminated fungal infections in very lowbirth-weight infants: clinical manifestations and epidemiology . Pediatrics . 1984;; 73:144-152.
2 +
Johnson DE, Thompson TR, Green TP, Ferrieri P.  Systemic candidiasis in very low-birth-weight infants (<1500 grams) . Pediatrics . 1984;;73:138-143.
3 +
Baley JE, Annable WL, Kliegman RM.  Candida endophthalmitis in the premature infant . J Pediatr . 1981;;98:458-461.
4 +
Faix RG.  Systemic Candida infections in infants in intensive care nurseries: high incidence of central nervous system involvement . J Pediatr . 1984;;105:616-622.
5 +
Thron A, Wietholter H.  Cerebral candidiasis: CT studies in a case of brain abscess and granuloma due to Candida albicans . Neuroradiology . 1982;;23:223-225.
6 +
Ikeda K, Yamashita J, Fujisawa H, Fujita S.  Cerebral granuloma and meningitis caused by Candida albicans: useful monitoring of mannan antigen in cerebrospinal fluid . Neurosurgery . 1990;;26:860-863.

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