Article |

A Randomized Controlled Trial of Penicillin vs Clindamycin for the Treatment of Aspiration Pneumonia in Children

Sheila J. Jacobson, MBBCh; Kathryn Griffiths; Shelley Diamond; Patricia Winders, RN; Michael Sgro, MD; William Feldman, MD; Colin Macarthur, MBBCh, PhD
Arch Pediatr Adolesc Med. 1997;151(7):701-704. doi:10.1001/archpedi.1997.02170440063011.
Text Size: A A A
Published online

Objective:  To compare the effectiveness of intravenous penicillin vs clindamycin for the treatment of aspiration pneumonia.

Design:  A double-blind, randomized controlled trial.

Setting:  A tertiary care pediatric hospital.

Patients:  We enrolled 42 children, aged 6 months to 18 years, who were admitted to the hospital for the treatment of aspiration pneumonia. All of the children had underlying conditions that predispose to aspiration.

Intervention:  The patients were randomly assigned to receive intravenous penicillin G sodium, 250 000 U/kg every 24 hours, or intravenous clindamycin phosphate, 30 mg/kg every 24 hours.

Main Outcome Measure:  The primary outcome measure was "time to ready for discharge" from the hospital.

Results:  In an effectiveness (intention to treat) analysis, the median time (interquartile range) to ready for discharge from the hospital was 4.9 days (range, 2.8-6.5 days) in the penicillin-treated group and 3.4 days (range, 2.3-6.8 days) in the clindamycin-treated group (P=.66). Results were not markedly altered when adjusted for the age difference of the groups or in the efficacy analysis (after the exclusion of 9 patients who withdrew from the trial). Rates for readmission to the hospital were similar in the 2 groups.

Conclusion:  Penicillin and clindamycin seem to be equally effective for the treatment of aspiration pneumonia in children hospitalized for this illness.Arch Pediatr Adolesc Med. 1997;151:701-704


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.