We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Resumption of Menses in Anorexia Nervosa-Reply

Tomas J. Silber, MD, MASS
Arch Pediatr Adolesc Med. 1997;151(6):635. doi:10.1001/archpedi.1997.02170430100025.
Text Size: A A A
Published online


Dr Needles questions whether the Frisch hypothesis might not hold if one would exclude the population with a "sick hypothalamus." There is no simple answer, because both menarche and the maintenance of regular periods are influenced by a variety of factors such as the family history, level of stress, amount and type of exercise, dietary intake, and many other events. Among them, the percentage of body fat can certainly be influential, but it is not, as has been statistically demonstrated, the determining factor.1 The best reply is to consider that loss of menses in anorexia nervosa is multifactorial. Hypothalamic dysfunction has classically been demonstrated in patients with anorexia nervosa by their immature secretory patterns of luteinizing hormone2 and their blunted response of luteinizing hormone to gonadotropin-releasing hormone.3 Almost a quarter century ago, Sherman et al3 showed normalization of the luteinizing hormone response to gonadotropin-releasing hormone when


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.