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Anti-inflammatory Therapy Reduces Wheezing After Bronchiolitis

Amin Hakim, MD
Arch Pediatr Adolesc Med. 1997;151(1):108-109. doi:10.1001/archpedi.1997.02170380112028.
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The study of Reijonen et al1 is interesting, but it does not provide important information about the severity of bronchiolitis, therapy administered, or oxygen requirements. Consequently, it lacks an analysis of the potential influence of these factors on the study results. The study was not blinded, and bias cannot be excluded. The authors do not define how early anti-inflammatory therapy was started in the course of the illness. There are no data on subsequent viral infections or the cause of initial infection. The incidence of postbronchiolitis wheezing is high in their study. Other authors have observed lower rates, eg, McConnochie and Roghmann2 found an incidence of 44% in a historical cohort with bronchiolitis during infancy vs 13% in normal population. On further analysis of confounding factors, 9% of wheezing was attributable to bronchiolitis. Regardless of the differences among studies, the rate of rehospitalization (almost half) is higher than that


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