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Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk

Enid Gilbert-Barness, MD
Arch Pediatr Adolesc Med. 1996;150(5):564. doi:10.1001/archpedi.1996.02170300118039.
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This compendium lists drugs in alphabetical order, with each discussed under fetal risk and breast-feeding summaries. A list of recent references is included.

Since the previous edition, published in 1990, more than 100 new drugs have been added. The authors have included animal studies, but they correctly point out that, although such studies may be predictive for the human, the accuracy depends on the species used and other factors. Much of the original information was derived from the collaborative Perinatal Project published in Birth Defects and Drugs in Pregnancy in 1977 and has been the "gold standard" for teratologists. This edition includes, however, data from a more recent and larger surveillance that covers more than 229 000 completed pregnancies over a 7-year period (1985 through 1992) from the Epidemiology and Surveillance Center for Drugs and Biologicals of the US Food and Drug Administration. The authors established a risk factor for


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