0
May 1996, Vol 150, No. 5 >
Article | May 1996

Pathological Case of the Month FREE

Teri A. Kahn, MD; Maritza O. Liranzo, MD; Allison T. Vidimos, MD; Frank A. Papay, MD; Wilma F. Bergfeld, MD
Arch Pediatr Adolesc Med. 1996;150(5):549-550. doi:10.1001/archpedi.1996.02170300103021.
Text Size: A A A
Published online
Article
References
Comments

A HEALTHY 15-YEAR-OLD white female presented with three asymptomatic lesions on her left breast that had been present since birth. The lesions were initially pink maculae that developed into pink nodules after puberty. On physical examination she had two soft, erythematous nodules with atrophic skin and overlying telangiectasia above her left breast. One ill-defined, indurated, violaceous plaque was present above the two soft nodules (Figure 1). There was no hepatosplenomegaly or lymphadenopathy. No other similar cutaneous lesions were identified in this patient. Laboratory investigation revealed a normal complete blood cell count and white blood cell differential. Total cholesterol was mildly elevated at 4.76 mmol/L (184 mg/dL) (normal, 1.94-4.37 mmol/L [75-169 mg/dL]). The biopsy results of one of the nodules are shown in Figure 2.

Diagnosis and Discussion

Congenital Dermatofibrosarcoma Protuberans

Histologic examination revealed a proliferation of atypical plump spindle cells within the dermis extending to the subcutaneous tissue in a

REFERENCES

1 +
Annessi G, Cimitan A, Girolomoni G, Giannetti A.  Congenital dermatofibrosarcoma protuberans . Pediatr Dermatol . 1993;;10:40-42.
2 +
McKee PH, Fletcher CD.  Dermatofibrosarcoma protuberans presenting in infancy and childhood . J Cutan Pathol . 1991;;18:241-246.
3 +
Taylor HB, Helwig EB.  Dermatofibrosarcoma protuberans: a study of 115 cases . Cancer . 1962;;15:717-725.
4 +
Kamino H, Jacobson M.  Dermatofibroma extending into the subcutaneous tissue: differential diagnosis from dermatofibrosarcoma protuberans . Am J Surg Pathol . 1990;;14:1156-1164.
5 +
Connelly JH, Evans HL.  Dermatofibrosarcoma protuberans: a clinicopathologic review with emphasis on fibrosarcomatous areas . Am J Surg Pathol . 1992;; 16:921-925.
6 +
Kutxner H, Germany F.  Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue . J Am Acad Dermatol . 1993;;28:613-617.
7 +
Cohen PR, Rappini RP, Farhood Al.  Expression of the human hematopoietic progenitor cell antigen CD34 in vascular and spindle cell tumors . J Cutan Pathol . 1993;;20:15-20.
8 +
Hobbs ER, Wheeland RG, Bailin PL, Ratz JL, Yetman RJ, Zins JE.  Treatment of dermatofibrosarcoma protuberans with Mohs micrographic surgery . Ann Surg . 1988;;207:102-107.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Annessi G, Cimitan A, Girolomoni G, Giannetti A.  Congenital dermatofibrosarcoma protuberans . Pediatr Dermatol . 1993;;10:40-42.
2 +
McKee PH, Fletcher CD.  Dermatofibrosarcoma protuberans presenting in infancy and childhood . J Cutan Pathol . 1991;;18:241-246.
3 +
Taylor HB, Helwig EB.  Dermatofibrosarcoma protuberans: a study of 115 cases . Cancer . 1962;;15:717-725.
4 +
Kamino H, Jacobson M.  Dermatofibroma extending into the subcutaneous tissue: differential diagnosis from dermatofibrosarcoma protuberans . Am J Surg Pathol . 1990;;14:1156-1164.
5 +
Connelly JH, Evans HL.  Dermatofibrosarcoma protuberans: a clinicopathologic review with emphasis on fibrosarcomatous areas . Am J Surg Pathol . 1992;; 16:921-925.
6 +
Kutxner H, Germany F.  Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue . J Am Acad Dermatol . 1993;;28:613-617.
7 +
Cohen PR, Rappini RP, Farhood Al.  Expression of the human hematopoietic progenitor cell antigen CD34 in vascular and spindle cell tumors . J Cutan Pathol . 1993;;20:15-20.
8 +
Hobbs ER, Wheeland RG, Bailin PL, Ratz JL, Yetman RJ, Zins JE.  Treatment of dermatofibrosarcoma protuberans with Mohs micrographic surgery . Ann Surg . 1988;;207:102-107.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems