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Neurobiology of Sleep Disturbances in Children With Atopic Dermatitis

Ernest H. Friedman, MD
Arch Pediatr Adolesc Med. 1996;150(3):329. doi:10.1001/archpedi.1996.02170280099022.
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In their recent article, Dahl et al1 state that 24 female subjects with atopic dermatitis had more difficulty falling asleep (P=.02) than did 35 male subjects with the same skin inflammation. The neurobiologic manifestations are suggested by reports linking immune function and wakefulness to dopamine lateralized to the right hemisphere, in which the metabolic rate is higher in females.2 The fact that delay-dependent speeding of reaction time, indicating motor readiness, is abolished by depletion of dopamine subserving mood prompts neurochemical and pharmacotherapeutic investigation3,4 of disruption of family activities because of aggressive behavior1 by monitoring speech hesitation and switching pauses, reflecting properties of neuronal activity and firing.3 This method is supported by anger attacks reflecting central hyposerotonergic function,5 serotonergic-mediated inhibition of dopamine, optimal response organization at intermediate dopamine tone in a medial-frontal-striatal activation system,2 and deactivation of the right hemisphere, a state marker


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