0
Article |

Long-term Outcome of Haemophilus influenzae Meningitis in Navajo Indian Children

Carl T. D'Angio, MD; Robert G. Froehlke, MD; Gary A. Plank, PhD; David J. Meehan, MD; Christine M. Aguilar, MD; Marc B. Lande, MD; Lily Hugar, MA
Arch Pediatr Adolesc Med. 1995;149(9):1001-1008. doi:10.1001/archpedi.1995.02170220067009.
Text Size: A A A
Published online

Objectives:  To determine the long-term neurologic, cognitive, and educational outcomes of Navajo children who survived Haemophilus influenzae type b meningitis.

Design:  Retrospective cohort study, with 3.6- to 15.0-year follow-up.

Setting:  Navajo Indian reservation.

Participants:  Population-based cohort of 76 Navajo children with Haemophilus meningitis at less than 5 years of age between 1975 and 1986, with 41(54%) consenting to undergo follow-up in 1990. Each case was matched to one nearest-age sibling and one unrelated age-matched control.

Main Outcome Measures:  Standardized intelligence test scores, neurologic abnormalities, and school performance.

Results:  The mean IQ for cases was lower than that for siblings (79 vs 87, P=.006) or age-matched controls (79 vs 95, P<.001). Twenty-nine percent of cases had severe neurologic sequelae, including mental retardation (24%), severe hearing loss (5%), cerebral palsy (7%), and seizure disorder (12%). Eight percent of siblings (relative risk for cases vs siblings, 8.0; P=.05) and 2% of age--matched controls (relative risk vs cases, 10.0; P=.01) had mental retardation. No siblings or age-matched controls had any other severe neurologic sequela. Twenty-nine percent of cases, 23% of siblings (relative risk, 2.5; P=.45), and 0% of age-matched controls (P=.001) required special education services, while 42% of cases, 23% of siblings (relative risk, 3.3; P=.10), and 11% of age-matched controls (relative risk, 4.0; P=.005) had been retained in a grade in school.

Conclusions:  Navajo survivors of Haemophilus meningitis suffer more long-term neurologic, cognitive, and school-related disability than siblings or age-matched controls. They may also suffer higher morbidity than Haemophilus meningitis survivors in the general population.(Arch Pediatr Adolesc Med. 1995;149:1001-1008)

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();