0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Sinus Histiocytosis With Massive Lymphadenopathy

Leslie L. Barton, MD
Arch Pediatr Adolesc Med. 1995;149(3):340-341. doi:10.1001/archpedi.1995.02170150120025.
Text Size: A A A
Published online

I am writing in reference to Case 1 of the Pathological Cases of the Month in the July issue of the Archives.1 The clinical and pathologic data in this infant support the diagnosis of sinus histiocytosis with massive lymphadenopathy, Rosai-Dorfman disease. Although the patient had serologic tests for a number of viruses, neither serologic testing for human herpesvirus 6 (HHV-6) nor examination of tissue for HHV-6 was performed. In a recent publication, Levine et al2 demonstrated the presence of detectable HHV-6 by in situ hybridization in seven of nine patient biopsy specimens examined. Tissue from one patient had detectable Epstein-Barr virus genome and another had no detectable HHV-6 or Epstein-Barr virus. Thus, in some instances, HHV-6, and occasionally Epstein-Barr virus and other viruses, may initiate sinus histiocytosis with massive lymphadenopathy. I also would suggest that the spectrum of pediatric disease caused by infection with Rochalimaea (Bartonella) henselae3

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();