A 2550-G, MALE NEWBORN, 36 weeks of gestational age, was noted to have mild facial dysmorphism and was referred for a genetic evaluation. A sibling was said to have a chromosomal abnormality. These are indications for chromosomal analysis. A peripheral blood sample was obtained from the newborn, and cytogenetic procedures followed. All metaphase cells analyzed by routine trypsin-Giemsa banding suggested an interchromosomal insertional translocation (Figure 1). This impression was elegantly confirmed by fluorescence in situ hybridization (FISH) technique (Figure 2).
The Editors welcome contributors to Pathological Case of the Month, Picture of the Month, and Radiological Case of the Month. Those who wish to contribute should send their manuscripts to Dr Gilbert-Barness (Pathological Case of the Month), Department of Pathology, Tampa General Hospital, University of South Florida, Davis Island, Tampa, FL 33606; Dr Tunnessen (Picture of the Month), The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard,