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Immune Thrombocytopenic Purpura in Infants

Jeffrey D. Hord, MD; James A. Whitlock, MD; Neil J. Grossman, MD
Arch Pediatr Adolesc Med. 1994;148(3):333-334. doi:10.1001/archpedi.1994.02170030103033.
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Acute immune thrombocytopenic purpura (ITP) is a well-described illness in preschool and young school-aged children and is usually self-limited. It has been suggested that infants with acute ITP do not respond to conventional therapy as well as children between ages 1 and 8 years and are more likely to

Comparison of Acute Immune Thrombocytopenic Purpura in infants and Older Children Variable Infants All Children (Published Data) Mean age Mean platelet count at diagnosis, ×109/L M:F ratio Intracranial hemorrhage Chronic Time to platelet count >100×109/L After oral steroids After intravenous steroids After intravenous IgG Under observation 7.8 mo 12.9 (range, 3-38) 1:1 None 1/10 3/3 by day 22 2/4 by day 2 and incomplete follow-up in other 2 2/2 by day 7 2/2 by day 55 Approximately 5 y2,3 100-3004,5 1:16 <1%7 10%-30%8-10 >60% by day 219,10 >60% with platelet count >50×109/L by day 52,4 >60% by day 79 80% spontaneous


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