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February 1994, Vol 148, No. 2 >
Article | February 1994

Decreased Plasma Concentrations of the C4B Complement Protein in Autism FREE

Reed P. Warren, PhD; Roger A. Burger, MS; Dennis Odell, MD; Anthony R. Torres, MD; W. Louise Warren, RN
Arch Pediatr Adolesc Med. 1994;148(2):180-183. doi:10.1001/archpedi.1994.02170020066011.
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Objective:  To determine complement C4 protein concentrations in the plasmas of autistic subjects and their family members.

Design:  Cross-sectional study.

Setting:  Center for Persons with Disabilities and the Department of Biology, Utah State University, Logan.

Participants:  Forty-two autistic subjects (34 males [81%] and eight females [19%]), 50 of their biologic parents, 21 siblings, and 105 normal subjects (56 females [53%] and 49 males [47%]; all white) living in northern Utah.

Interventions:  None.

Methods:  The enzyme-linked immunosorbent assay was used to determine C4 protein concentrations in autistic subjects.

Main Results:  Plasma concentration (median, 14.7 g/L of the C4B protein) in autistic patients was significantly (P=.01) decreased compared with that of normal subjects (median, 22.4 g/L). The C4B concentrations in parents and siblings of autistic children were decreased, but not significantly. The C4A protein concentrations in the plasma of autistic subjects and their family members were normal.

Conclusion:  Decreased protein concentrations of C4B may be associated with autism.(Arch Pediatr Adolesc Med. 1994;148:180-183)

REFERENCES

1 +
Suciu-Foca N, King DW.  The HLA system: structure and function . In: Sampter M, Talmage DW, Frank MM, Austen KF, Claman HN, eds. Immunological Diseases . 4th ed. Boston, Mass: Little, Brown & Co Inc; 1988;:385-407.
2 +
Warren RP, Singh VK, Cole P, et al.  Increased frequency of the null allele at the complement C4B locus in autism . Clin Exp Immunol . 1991;;83:438-440.
3 +
Isenman DE, Young JR.  Covalent binding of the C4A and C4B isotypes of the fourth component of human complement on several C1 bearing-cell surfaces . J Immunol . 1986;;136:2542-2550.
4 +
American Psychiatric Association, Committee on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition . Washington, DC: American Psychiatric Association; 1987;.
5 +
Rebmann, V, Doxiadis I, Kubens BS, Grosse-Wilde H.  Quantitation of the human component C4: definition of C4Q0 alleles and C4A duplications . Vox Sang . 1992;;62:117-123.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Suciu-Foca N, King DW.  The HLA system: structure and function . In: Sampter M, Talmage DW, Frank MM, Austen KF, Claman HN, eds. Immunological Diseases . 4th ed. Boston, Mass: Little, Brown & Co Inc; 1988;:385-407.
2 +
Warren RP, Singh VK, Cole P, et al.  Increased frequency of the null allele at the complement C4B locus in autism . Clin Exp Immunol . 1991;;83:438-440.
3 +
Isenman DE, Young JR.  Covalent binding of the C4A and C4B isotypes of the fourth component of human complement on several C1 bearing-cell surfaces . J Immunol . 1986;;136:2542-2550.
4 +
American Psychiatric Association, Committee on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition . Washington, DC: American Psychiatric Association; 1987;.
5 +
Rebmann, V, Doxiadis I, Kubens BS, Grosse-Wilde H.  Quantitation of the human component C4: definition of C4Q0 alleles and C4A duplications . Vox Sang . 1992;;62:117-123.

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