We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Treatment of Visceral Leishmaniasis With Meglumine and Allopurinol

Am J Dis Child. 1993;147(6):611-612. doi:10.1001/archpedi.1993.02160300017011.
Text Size: A A A
Published online

Sir.—Özsoylu1 presented the results of his study on visceral leishmaniasis and its treatment in children in the September 1992 issue of AJDC. We want to present our results with a different combined treatment: meglumine antimonate (as Glucantim) and allopurinol.

We describe 110 children with visceral leishmaniasis ranging in age from 6 months to 6 years. In most children, the disease had the typical picture of irregular fever, liver and spleen enlargement, anemia, and pancytopenia. All children were in satisfactory clinical condition; the diagnosis was confirmed by the presence of Leishmania donovani in bone marrow. Forty-six patients, diagnosed from 1973 through 1985, received conventional treatment with intramuscular meglumine antimonate alone (100 mg/kg daily) for 30 days.2

From 1986 through 1992, we used allopurinol and pentavalent antimony in the treatment of 64 patients admitted in our department who were diagnosed as having visceral leishmaniasis. They received allopurinol (25 mg/kg


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.