Cholesterol Measurement in Children FREE

PAULA T. EINHORN, MD; BASIL M. RIFKIND, MD

Am J Dis Child. 1993;147(4):373-375. doi:10.1001/archpedi.1993.02160280023011.

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ABSTRACT

ABSTRACT | REFERENCES

The atherosclerotic process begins in childhood and progresses slowly into adulthood. Aortic fatty streaks occur in individuals as young as 3 years old,¹ and coronary fatty streaks occur in more than half of children aged 10 to 14 years. Approximately 8% of individuals aged 10 to 14 years have more advanced lesions.^2,3 Pathologic studies^4,5 have shown gross evidence of coronary disease in young soldiers killed in the Korean and Vietnam conflicts. Vascular changes have been shown to correlate with blood cholesterol levels in the Bogalusa Heart Study^6,7 and in the Pathobiological Determinants of Atherosclerosis in Youth Program.⁸ Postmortem arterial lesions were positively related to antemortem lowdensity and very-low-density cholesterol levels and negatively related to antemortem high-density lipoprotein cholesterol levels. International data revealed that cholesterol levels in children vary geographically; in countries with high coronary heart diseaserelated

REFERENCES

ABSTRACT | REFERENCES

Holman RL, McGill HC Jr, Strong JP, Geer JC. The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the 20th century . Am J Pathol . 1958;; 34:209-235.

Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults . Arteriosclerosis . 1989;;9 ( (suppl 1) ):1-19-1-32.

Stary HC. The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first 40 years of life . Eur Heart J . 1990;;11 ( (suppl E) ):3-19.

Strong JP. Coronary atherosclerosis in soldiers: a clue to the natural history of atherosclerosis in the young . JAMA . 1986;;256:2863-2866.

McNamara JJ, Molot MA, Stremple JF, Cutting RT. Coronary artery disease in combat casualties in Vietnam . JAMA . 1971;;216:1185-1187.

Freedman DS, Newman WP III, Tracy RE, et al. Black-white differences in aortic fatty streaks in adolescence and early adulthood: the Bogalusa Heart Study . Circulation . 1988;;77:856-864.

Newman WP III, Wattigney W, Berenson GS. Autopsy studies in US children and adolescents: relationship of risk factors to atherosclerotic lesions . Ann N Y Acad Sci . 1991;;623:16-25.

PDAY Research Group. Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking: a preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group . JAMA . 1990;;264: 3018-3024.

Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. National Cholesterol Education Program . Pediatrics . 1992;;89( (suppl) ):525-584.

Sprecher DL, Schaefer EJ, Kent KM, Gregg RE, Zech La, Hoeg JM. Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients . Am J Cardiol . 1984;;54:20-30.

Clinical Laboratory Improvements Amendments of 1988. Pub L No. 100-578, 102 Stat 2903.

Laboratory Standardization Panel of the National Cholesterol Education Program. Recommendations for Improving Cholesterol Measurement . Bethesda, Md: National Institutes of Health; 1990;. Publication 90-2963.

Bennett MJ, Tershakovec AM, Cortner JA, Shannon BM. A quality assurance program for the measurement of capillary blood cholesterol levels in private pediatric practices . AJDC . 1993;; 147:340-345.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal