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Article |

Which Child Will Have a Febrile Seizure?

Peggy Bethune, MD; Kevin Gordon, MD, MS; Joseph Dooley, MB; Carol Camfield, MD; Peter Camfield, MD
Am J Dis Child. 1993;147(1):35-39. doi:10.1001/archpedi.1993.02160250037013.
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• Objective.  —To identify risk factors predictive of a first febrile seizure.

Design.  —Case-control study.

Setting.  —Regional referral pediatric hospital emergency department.

Patients.  —Seventy-five patients aged 6 months to 4 years presenting with a first febrile seizure were age-matched to two febrile and two afebrile noninfectious controls who had never had a seizure.

Methods.  —Telephone interview of parents.

Main Outcome Measures.  —Risk factors assessed included family history of febrile or afebrile seizures, neurodevelopmental abnormality, and child-care arrangement. Analysis was done by matched case-control and logistic regression.

Results.  —Factors associated with a significant increase in risk of a first febrile seizure were febrile seizures in first-degree relative (odds ratio [OR], 4.5) or second-degree relative (OR, 3.5); neonatal discharge at 28 days or later (OR, 5.6); parental report of "slow" development (OR, 4.9); and day-care attendance (OR, 3.1). For children with two risk factors (an estimated 3% of the population), the risk of developing febrile seizures is approximately 28% (assuming a population incidence of febrile seizures of 4%).(AJDC. 1993;147:35-39)

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