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Pathological Case of the Month

Sami B. Elhassani, MD; Enid Gilbert-Barness, MD
Am J Dis Child. 1992;146(9):1097-1098. doi:10.1001/archpedi.1992.02160210099032.
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Diagnosis and Discussion May-Hegglin Anomaly

A 3200-g girl was delivered after a full-term pregnancy to a 31-year-old gravida 1, blood type A+ white mother. Pregnancy and delivery were uncomplicated. The mother, maternal grandmother, mother's brother, and infant's half sister were afflicted with a rare hematologic disorder involving platelet dysfunction. The infant's initial platelet count was 58×109/L, and the lowest value was 51×109/L. Clinically, the infant's hospital course was uneventful; and after 4 days, she was discharged. Figs 1 and 2 depict peripheral blood smears.

May-Hegglin anomaly, a rare genetic disorder manifested by characteristic peripheral blood smear findings involving neutrophils and platelets, usually occurs in asymptomatic individuals. The constellation of the blood cytologic feature of May-Hegglin anomaly bears the names of the original describers of the condition: May in 19091 and Hegglin in 1945.2 The autosomal dominant mode of inheritance of the disease was first

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