0
August 1992, Vol 146, No. 8 >
Article | August 1992

Agnogenic Myeloid Metaplasia in Children FREE

Ahmad A. Mallouh, MD; A. Rahman Sa'di, MD
[+] Author Affiliations

Accepted for publication February 11, 1992.

Reprint requests to the Saudi Aramco—Dhahran Health Center, Box 76, Dhahran 31311, Saudi Arabia (Dr Mallouh).


Am J Dis Child. 1992;146(8):965-967. doi:10.1001/archpedi.1992.02160200087034.
Text Size: A A A
Published online
Article
References
Comments

• Agnogenic myeloid metaplasia is a chronic myeloproliferative disorder characterized by splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis, teardrop-shaped red blood cells, and fibrosis of the bone marrow. It is a disease of adults, with only one case report in the pediatric literature. The symptoms of the patient in this case clearly fit the diagnostic criteria of this disease. Myelofibrosis in children is usually of the acute type, presenting in infancy and running a fulminant, fatal course with minimal or mild splenomegaly. Red blood cells are usually normal on morphologic examination.Three infants, including two siblings, presented at ages 9, 10, and 16 months with clinical and laboratory findings consistent with agnogenic myeloid metaplasia. The occurrence of the disease in these siblings is suggestive of an autosomal recessive mode of inheritance.

(AJDC. 1992;146:965-967)

REFERENCES

1 +
Boxer LA, Camitta BM, Berenberg W, Fanning JP.  Myelofibrosis-myeloid metaplasia in childhood . Pediatrics . 1975;;55:861-865.
2 +
Silverstein MN, Remine WH.  Splenectomy in myeloid metaplasia . Blood . 1979;;53:515-518.
3 +
Wolf BC, Neiman RS.  Myelofibrosis with myeloid metaplasia: pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly . Blood . 1985;;65:803-809.
4 +
Schwartz CL, Cohen HJ.  Preleukemia syndromes and other syndromes predisposing to leukemia . Pediatr Clin North Am . 1988;;35:853-871.
5 +
Wolf BC, Neiman RS.  The bone marrow in myeloproliferative and dysmyelopoietic syndromes . Hematol Oncol Clin North Am . 1988;;2:669-694.
6 +
Njoku OS, Lewis SM, Catovsky D, Gordan-Smith EC.  Anaemia in myelofibrosis: its value in prognosis . Br J Haematol . 1983;;54:79-89.
7 +
Ward HP, Block MH.  The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with myeloproliferative syndrome . Medicine . 1971;;50:357-420.
8 +
Laszlo J.  Myeloproliferative disorders (MPD): myelofibrosis, myelosclerosis, extramedullary hematopoiesis, undifferentiated MPD and hemorrhagic thrombocythemia . Sem Hematol . 1975;;12:409-432.
9 +
Rosenthal DS, Moloney WC.  Myeloid metaplasia: a study of 98 cases . Postgrad Med . 1969;;45:136-142.
10 +
O'Donnell JR, Farrell MA, Fitzgerald MX, O'Connell LGO.  Agnogenic myeloid metaplasia preceded by repeated leukemoid reaction and persistent acquired Pelger-Huet anomaly of granulocytes: case report with review of acquired Pelger-Huët anomaly . Cancer . 1982;;50:1498-1505.
11 +
Linman JW, Bethell FH.  Agnogenic myeloid metaplasia: its natural history and present day management . Am J Med . 1957;;22:107-122.
12 +
Demory JL, Dupriez B, Fenaux P, et al.  Cytogenetic studies and their prognostic significance in agnogenic myeloid metaplasia: a report of 47 cases . Blood . 1988;;72:855-859.
13 +
Gilbert HS.  The spectrum of myeloproliferative disorders . Med Clin North Am . 1973;;57:355-393.
14 +
Say B, Berkel I.  Idiopathic myelofibrosis in an infant . J Pediatr . 1964;; 64:580-585.
15 +
McCarthy DM.  Fibrosis of the bone marrow: contents and causes . Br J Haematol . 1985;;59:1-7.
16 +
Grier HE.  Chronic myeloproliferative disorders and myelodysplasia . In: Nathan DG, Oski Fa, eds. Hematology of Infancy and Childhood . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1987;:1064-1085.
17 +
Randall DL, Reiquam CW, Githens JH, Robinson A.  Familial myeloproliferative disease: a new syndrome closely simulating myelogenous leukemia in childhood . AJDC . 1965;;110:479-499.
18 +
Sieff CA, Malleson P.  Familial myelofibrosis . Arch Dis Child . 1980;; 55:888-893.
19 +
Schlackman N, Green AA, Naiman JL.  Myelofibrosis in children with chronic renal insufficiency . J Pediatr . 1975;;87:720-724.
20 +
Cooperberg AA, Singer OP.  Reversible myelofibrosis due to vitamin D deficiency rickets . Can Med Assoc J . 1966;;94:392-395.
21 +
Yetgin S, Ozsoylu S.  Myeloid metaplasia in vitamin D deficiency rickets . Scand J Haematol . 1982;;28:180-185.
22 +
Yetgin S, Ozsoylu S, Ruacan S, Tekinalp G, Sarialioglue F.  Vitamin D deficiency rickets and myelofibrosis . J Pediatr . 1989;;114:213-217.
23 +
Rosemberg HS, Taylor FM.  The myeloproliferative syndrome in children . J Pediatr . 1958;;52:407-415.
24 +
Evans DIK.  Acute myelofibrosis in children with Down's syndrome . Arch Dis Child . 1975;;50:458-462.
25 +
Nordan UZ, Humbert JR.  Myelofibrosis and acute lymphoblastic leukemia in a child with Down's syndrome . J Pediatr . 1979;;94:253-255.
26 +
Balfanz JR, Nesbit ME, Krivit W.  Bone marrow curettage in childhood myelofibrosis . J Pediatr . 1975;;87:578-580.
27 +
Brovall C, Mitchell H, Saral R, Santos GW, Civin CI.  Acute myelofibrosis in a child . J Pediatr . 1983;;103:91-93.
28 +
Benbassat J, Penchas S, Ligumski M.  Splenectomy in patients with agnogenic myeloid metaplasia: an analysis of 321 published cases . Am J Hematol . 1979;;42:207-214.
29 +
Calabro JJ, Lonino Jr AV, Eyvazzadeh C.  Juvenile rheumatoid arthritis: an overview . In: Hicks RV, ed. Vasculopathies of Childhood . Littleton, Mass: John Wright-PSG Inc; 1988;:101-155.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Boxer LA, Camitta BM, Berenberg W, Fanning JP.  Myelofibrosis-myeloid metaplasia in childhood . Pediatrics . 1975;;55:861-865.
2 +
Silverstein MN, Remine WH.  Splenectomy in myeloid metaplasia . Blood . 1979;;53:515-518.
3 +
Wolf BC, Neiman RS.  Myelofibrosis with myeloid metaplasia: pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly . Blood . 1985;;65:803-809.
4 +
Schwartz CL, Cohen HJ.  Preleukemia syndromes and other syndromes predisposing to leukemia . Pediatr Clin North Am . 1988;;35:853-871.
5 +
Wolf BC, Neiman RS.  The bone marrow in myeloproliferative and dysmyelopoietic syndromes . Hematol Oncol Clin North Am . 1988;;2:669-694.
6 +
Njoku OS, Lewis SM, Catovsky D, Gordan-Smith EC.  Anaemia in myelofibrosis: its value in prognosis . Br J Haematol . 1983;;54:79-89.
7 +
Ward HP, Block MH.  The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with myeloproliferative syndrome . Medicine . 1971;;50:357-420.
8 +
Laszlo J.  Myeloproliferative disorders (MPD): myelofibrosis, myelosclerosis, extramedullary hematopoiesis, undifferentiated MPD and hemorrhagic thrombocythemia . Sem Hematol . 1975;;12:409-432.
9 +
Rosenthal DS, Moloney WC.  Myeloid metaplasia: a study of 98 cases . Postgrad Med . 1969;;45:136-142.
10 +
O'Donnell JR, Farrell MA, Fitzgerald MX, O'Connell LGO.  Agnogenic myeloid metaplasia preceded by repeated leukemoid reaction and persistent acquired Pelger-Huet anomaly of granulocytes: case report with review of acquired Pelger-Huët anomaly . Cancer . 1982;;50:1498-1505.
11 +
Linman JW, Bethell FH.  Agnogenic myeloid metaplasia: its natural history and present day management . Am J Med . 1957;;22:107-122.
12 +
Demory JL, Dupriez B, Fenaux P, et al.  Cytogenetic studies and their prognostic significance in agnogenic myeloid metaplasia: a report of 47 cases . Blood . 1988;;72:855-859.
13 +
Gilbert HS.  The spectrum of myeloproliferative disorders . Med Clin North Am . 1973;;57:355-393.
14 +
Say B, Berkel I.  Idiopathic myelofibrosis in an infant . J Pediatr . 1964;; 64:580-585.
15 +
McCarthy DM.  Fibrosis of the bone marrow: contents and causes . Br J Haematol . 1985;;59:1-7.
16 +
Grier HE.  Chronic myeloproliferative disorders and myelodysplasia . In: Nathan DG, Oski Fa, eds. Hematology of Infancy and Childhood . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1987;:1064-1085.
17 +
Randall DL, Reiquam CW, Githens JH, Robinson A.  Familial myeloproliferative disease: a new syndrome closely simulating myelogenous leukemia in childhood . AJDC . 1965;;110:479-499.
18 +
Sieff CA, Malleson P.  Familial myelofibrosis . Arch Dis Child . 1980;; 55:888-893.
19 +
Schlackman N, Green AA, Naiman JL.  Myelofibrosis in children with chronic renal insufficiency . J Pediatr . 1975;;87:720-724.
20 +
Cooperberg AA, Singer OP.  Reversible myelofibrosis due to vitamin D deficiency rickets . Can Med Assoc J . 1966;;94:392-395.
21 +
Yetgin S, Ozsoylu S.  Myeloid metaplasia in vitamin D deficiency rickets . Scand J Haematol . 1982;;28:180-185.
22 +
Yetgin S, Ozsoylu S, Ruacan S, Tekinalp G, Sarialioglue F.  Vitamin D deficiency rickets and myelofibrosis . J Pediatr . 1989;;114:213-217.
23 +
Rosemberg HS, Taylor FM.  The myeloproliferative syndrome in children . J Pediatr . 1958;;52:407-415.
24 +
Evans DIK.  Acute myelofibrosis in children with Down's syndrome . Arch Dis Child . 1975;;50:458-462.
25 +
Nordan UZ, Humbert JR.  Myelofibrosis and acute lymphoblastic leukemia in a child with Down's syndrome . J Pediatr . 1979;;94:253-255.
26 +
Balfanz JR, Nesbit ME, Krivit W.  Bone marrow curettage in childhood myelofibrosis . J Pediatr . 1975;;87:578-580.
27 +
Brovall C, Mitchell H, Saral R, Santos GW, Civin CI.  Acute myelofibrosis in a child . J Pediatr . 1983;;103:91-93.
28 +
Benbassat J, Penchas S, Ligumski M.  Splenectomy in patients with agnogenic myeloid metaplasia: an analysis of 321 published cases . Am J Hematol . 1979;;42:207-214.
29 +
Calabro JJ, Lonino Jr AV, Eyvazzadeh C.  Juvenile rheumatoid arthritis: an overview . In: Hicks RV, ed. Vasculopathies of Childhood . Littleton, Mass: John Wright-PSG Inc; 1988;:101-155.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems